ReviewNeuroscience2009
Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development.
Review in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Neuroplasticity - exercise-induced response of peripheral brain-derived neurotrophic factor: a systematic review of experimental studies in human subjects.Sports medicine (Auckland, N.Z.) · 2010Pooled it
- Socioeconomic factors, brain-derived neurotrophic factor Val66Met polymorphism, and cortical structure in children and adolescents.Scientific reports · 2025Article
- The BDNF Val66Met polymorphism and health-related quality of life in youth with obesity.Physiological reports · 2024Article
- Genetic polymorphisms and post-stroke upper limb motor improvement - A systematic review and meta-analysis.Journal of central nervous system disease · 2024Article
- Early Life Stress AffectsInternational journal of molecular sciences · 2022Review
- Article
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Music-Based Intervention AmelioratesInternational journal of molecular sciences · 2021Article
- Maternal Separation-Induced Histone Acetylation Correlates with BDNF-Programmed Synaptic Changes in an Animal Model of PTSD with Sex Differences.Molecular neurobiology · 2021Article
- Time-varying Effects of GABRG1 and Maladaptive Peer Behavior on Externalizing Behavior from Childhood to Adulthood: Testing Gene × Environment × Development Effects.Journal of youth and adolescence · 2020Article
- Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood.BioMed research international · 2019Article
- Changes in neuroplasticity following early-life social adversities: the possible role of brain-derived neurotrophic factor.Pediatric research · 2019Review
- Mice engineered to mimic a common Val66Met polymorphism in the BDNF gene show greater sensitivity to reversal in environmental contingencies.Developmental cognitive neuroscience · 2018Article
- Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity.Biological psychiatry · 2018Review
- A genetic variant brain-derived neurotrophic factor (BDNF) polymorphism interacts with hostile parenting to predict error-related brain activity and thereby risk for internalizing disorders in children.Development and psychopathology · 2018Article
- No gene-by-environment interaction of BDNFEuropean journal of psychotraumatology · 2018Article
- 'Developmental Delay' Reconsidered: The Critical Role of Age-Dependent, Co-variant Development.Frontiers in psychology · 2018Article
- Harsh Parenting and Serotonin Transporter and BDNF Val66Met Polymorphisms as Predictors of Adolescent Depressive Symptoms.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2018Article
- Neurogenetic plasticity and sex influence the link between corticolimbic structural connectivity and trait anxiety.Scientific reports · 2017Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 1 country.
Funding
Abstract
There has been a dramatic rise in gene x environment studies of human behavior over the past decade that have moved the field beyond simple nature versus nurture debates. These studies offer promise in accounting for more variability in behavioral and biological phenotypes than studies that focus on genetic or experiential factors alone. They also provide clues into mechanisms of modifying genetic risk or resilience in neurodevelopmental disorders. Yet, it is rare that these studies consider how these interactions change over the course of development. In this paper, we describe research that focuses on the impact of a polymorphism in a brain-derived neurotrophic factor (BDNF) gene, known to be involved in learning and development. Specifically we present findings that assess the effects of genotypic and environmental loadings on neuroanatomic and behavioral phenotypes across development. The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.