ArticleInternational journal of cancer2009
Family history of colorectal cancer: a determinant of advanced adenoma stage or adenoma multiplicity?
Article in International journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Guideline
- The Prognostic and Clinicopathological Roles of PD-L1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2019Pooled it
- Family history and the natural history of colorectal cancer: systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2015Pooled it
- Evaluation of acylated/deacylated ghrelin, CCL20/CCR6 concentration, and IgG N-Glycan alterations in different dysplasia grades of colon adenoma.Glycoconjugate journal · 2026Article
- Lifestyle Change After Initial Colonoscopy Screening and Incidence of Colorectal Cancer and Major Chronic Diseases.The American journal of gastroenterology · 2025Article
- Sulforaphane Inhibits IL-1β-Induced IL-6 by Suppressing ROS Production, AP-1, and STAT3 in Colorectal Cancer HT-29 Cells.Antioxidants (Basel, Switzerland) · 2024Article
- Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations throughout the life course and risk of colorectal cancer precursors.British journal of cancer · 2023Article
- Relationship between fibrinogen level and advanced colorectal adenoma among inpatients: A retrospective case-control study.Frontiers in medicine · 2023Article
- Endoscopic Screening and Risk of Colorectal Cancer according to Type 2 Diabetes Status.Cancer prevention research (Philadelphia, Pa.) · 2022Article
- Risk Factors for Colorectal Adenocarcinoma in an Indigenous Population in East Africa.Cancer management and research · 2022Article
- Long-Term Colorectal Cancer Incidence and Mortality After Colonoscopy Screening According to Individuals' Risk Profiles.Journal of the National Cancer Institute · 2021Article
- Healthy lifestyle, endoscopic screening, and colorectal cancer incidence and mortality in the United States: A nationwide cohort study.PLoS medicine · 2021Article
- Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.Gastroenterology · 2020Article
- Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies.International journal of epidemiology · 2020Article
- Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer.International journal of cancer · 2019Article
- Outcomes of screening and surveillance in people with two parents affected by colorectal cancers: experiences from the Familial Bowel Cancer Service.Hereditary cancer in clinical practice · 2019Article
- Interendoscopist variability in proximal colon polyp detection is twice higher for serrated polyps than adenomas.World journal of gastroenterology · 2016Article
- Dietary habits of colorectal neoplasia patients in comparison to their first-degree relatives.World journal of gastroenterology · 2014Article
- Long-term colorectal-cancer incidence and mortality after lower endoscopy.The New England journal of medicine · 2013Article
- Identification of kininogen-1 as a serum biomarker for the early detection of advanced colorectal adenoma and colorectal cancer.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
A family history of colorectal cancer may increase colorectal cancer risk by influencing adenoma growth or enhancing the formation of new lesions. Data of men from the prospective Health Professionals Follow-Up Study who underwent an endoscopy between 1986 and 2004 were used to evaluate whether a family history of colorectal cancer is associated with adenoma multiplicity or advanced adenoma stage (> or =1 cm, histology with villous component or carcinoma in situ). 21.4% of the 3,881 adenoma patients and 13.9% of the 24,959 adenoma-free men had a first-degree relative with colorectal cancer. Thousand four hundred and ninety-six men were classified as having advanced and 1,507 as having nonadvanced adenomas. Six hundred and twenty-two men had multiple and 1,985 had single adenomas in the distal colon and rectum. A family history of colorectal cancer was similarly associated with advanced and nonadvanced adenomas [multivariable odds ratio (OR) (95% confidence interval): advanced vs. nonadvanced, 0.98 (0.82-1.17), advanced vs. adenoma-free: 1.67 (1.47-1.91), nonadvanced vs. adenoma-free: 1.70 (1.49-1.94)], although potential differences according to adenoma location were seen. A family history of colorectal cancer was more strongly associated with multiple distally located adenomas [odds ratio (95% confidence interval): multiple vs. single, 1.35 (1.09-1.68), multiple vs. no distally located adenomas: 2.02 (1.67-2.44), single vs. no distally located adenomas: 1.49 (1.32-1.68)]. The number of adenomas was also positively associated with a family history of colorectal cancer. Our findings suggest that at the population level, heritable factors may be more important in earlier stages of adenoma formation than at stages of adenoma advancement for at least distally located adenomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.