ArticleEuropean journal of epidemiology2009
Nonlinear association between serum testosterone levels and coronary artery disease in Iranian men.
Article in European journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
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- Non-linear correlation between amylase day 2 to day 1 ratio and incidence of severe acute pancreatitis.Frontiers in cellular and infection microbiology · 2022Article
- Association Between Androgenic Alopecia and Coronary Artery Disease: A Cross-Sectional Study of Han Chinese Male Population.International journal of general medicine · 2021Article
- Relationship between low-density lipoprotein cholesterol and severe acute pancreatitis ("the lipid paradox").Therapeutics and clinical risk management · 2018Article
- Testosterone as a marker of coronary artery disease severity in middle aged males.Indian heart journal · 2016Observational
- Testosterone is negatively associated with the severity of coronary atherosclerosis in men.Asian journal of andrology · 2012Article
- Cardiovascular and metabolic influences of fetal smoke exposure.European journal of epidemiology · 2011Review
- The Rotterdam Study: 2012 objectives and design update.European journal of epidemiology · 2011Article
- The Shanghai Changfeng Study: a community-based prospective cohort study of chronic diseases among middle-aged and elderly: objectives and design.European journal of epidemiology · 2010Article
- New studies, technology, and the progress of epidemiology.European journal of epidemiology · 2010Article
- The Generation R Study: design and cohort update 2010.European journal of epidemiology · 2010Article
- Early influences on cardiovascular and renal development.European journal of epidemiology · 2010Review
- Association between Androgenic Hormone Levels and Left Ventricular Ejection Fraction.The journal of Tehran Heart Center · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown controversial results about the role of androgens in coronary artery disease (CAD). We performed this study to examine and compare the relationship between androgenic hormones and CAD using conventional linear statistical techniques as well as novel non-linear approaches. The study was conducted on 502 consecutive men who were referred for selective coronary angiography at Tehran Heart Center due to different indications. We studied the relationship between androgenic hormones and CAD by using the generalized linear models, generalized additive models, and neural networks. Free testosterone (fT), total testosterone (tT) and dehydroepiandrosterone sulfate levels in patients with significant CAD versus normal individuals were 6.69 +/- 3.20 pg/ml, 16.60 +/- 6.66 nm/l, and 113.38 +/- 72.9 microg/dl versus 7.12 +/- 3.58 pg/ml, 15.82 +/- 7.26 nm/l, and 109.03 +/- 68.19 microg/dl, respectively (P > 0.05). The Generalized linear models was unable to show any significant relationship between androgenic hormones and CAD, while generalized additive model and neural networks supported the significant effect of androgenic hormones on CAD. This finding suggests a nonlinear association of tT levels with CAD: lower levels have a preventive effect on CAD, whereas higher values increase the risk of CAD. Emphasizing the non-linearity of the variables may provide new insight into the possible explanation of the effect of androgenic hormones on CAD.
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