ArticleNeurochemical research2009
Norepinephrine homogeneously inhibits alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat.
Article in Neurochemical research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- Astrocytes, Noradrenaline, α1-Adrenoreceptors, and Neuromodulation: Evidence and Unanswered Questions.Frontiers in cellular neuroscience · 2021Review
- Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment.Molecular neurobiology · 2019Review
- The αThe Journal of physiology · 2017Article
- Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?Frontiers in synaptic neuroscience · 2016Article
- Stimulus-specific effects of noradrenaline in auditory cortex: implications for the discrimination of communication sounds.The Journal of physiology · 2015Article
- Article
- Layer- and area-specificity of the adrenergic modulation of synaptic transmission in the rat neocortex.Neurochemical research · 2014Article
- Selective suppression of excitatory synapses on GABAergic interneurons by norepinephrine in juvenile rat prefrontal cortical microcircuitry.Neuroscience · 2013Article
- Locus coeruleus stimulation recruits a broad cortical neuronal network and increases cortical perfusion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Beyond traditional approaches to understanding the functional role of neuromodulators in sensory cortices.Frontiers in behavioral neuroscience · 2012Article
- Cortical state and attention.Nature reviews. Neuroscience · 2011Review
- The role of the central noradrenergic system in behavioral inhibition.Brain research reviews · 2011Review
- Information flow in the auditory cortical network.Hearing research · 2011Review
- Layer-specific noradrenergic modulation of inhibition in cortical layer II/III.Cerebral cortex (New York, N.Y. : 1991) · 2011Article
- Dynamic modulation of short-term synaptic plasticity in the auditory cortex: the role of norepinephrine.Hearing research · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The primary auditory cortex is subject to the modulation of numerous neurotransmitters including norepinephrine (NE), which has been shown to decrease cellular excitability by yet unclear mechanisms. We investigated the possibility that NE directly affects excitatory glutamatergic synapses. We found that bath applications of NE (20 microM) decreased glutamatergic excitatory post-synaptic currents (EPSCs) in all cortical layers. Changes in the kinetics of synaptic EPSCs, invariance of pair pulse ratio and of the coefficient-of-variation, together with the decrease of responses to pressure-application of AMPA (500 microM), indicated the postsynaptic nature of the adrenergic effect. Pharmacological experiments suggested that the NE-induced depression of EPSCs is caused by the activation of alpha1 adrenoceptors, PLC, and a Ca(2+)-independent PKC. We speculate that the decrease in temporal cortex excitability might promote a posterior-to-anterior shift in cortical activation together with a decrease in spontaneous background activity, resulting eventually in more effective sensory processing.
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Registered trials
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