ArticlePloS one2009
A hypomorphic vasopressin allele prevents anxiety-related behavior.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 73 citations in OpenAlex.
- Ameliorative Effect of Moringa oleifera Against CUMS-Induced Anxiety in Rats: β-Catenin and 5-HTMolecular neurobiology · 2025Article
- A Comprehensive Overview of Stress, Resilience, and Neuroplasticity Mechanisms.International journal of molecular sciences · 2025Review
- Article
- Modulation of social behavior by distinct vasopressin sources.Frontiers in endocrinology · 2023Review
- Reduction in vasopressin cells in the suprachiasmatic nucleus in mice increases anxiety and alters fluid intake.Hormones and behavior · 2021Article
- Sex Differences in the Control of Social Investigation and Anxiety by Vasopressin Cells of the Paraventricular Nucleus of the Hypothalamus.Neuroendocrinology · 2021Article
- Removal of vasopressin cells from the paraventricular nucleus of the hypothalamus enhances lipopolysaccharide-induced sickness behaviour in mice.Journal of neuroendocrinology · 2021Article
- Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020Review
- Vasopressin and alcohol: a multifaceted relationship.Psychopharmacology · 2018Review
- Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex.Translational psychiatry · 2018Article
- Selective Mitochondrial Targeting Exerts Anxiolytic Effects In Vivo.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Oxytocin Stimulates Extracellular Ca2+ Influx Through TRPV2 Channels in Hypothalamic Neurons to Exert Its Anxiolytic Effects.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Environmental manipulations generate bidirectional shifts in both behavior and gene regulation in a crossbred mouse model of extremes in trait anxiety.Frontiers in behavioral neuroscience · 2014Article
- Identification of a role for the ventral hippocampus in neuropeptide S-elicited anxiolysis.PloS one · 2013Article
- Co-segregation of hyperactivity, active coping styles, and cognitive dysfunction in mice selectively bred for low levels of anxiety.Frontiers in behavioral neuroscience · 2013Article
- The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety.BMC genomics · 2012Article
- Anxiety- rather than depression-like behavior is associated with adult neurogenesis in a female mouse model of higher trait anxiety- and comorbid depression-like behavior.Translational psychiatry · 2012Article
- Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Animal models of stress vulnerability and resilience in translational research.Current psychiatry reports · 2012Review
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate neurobiological correlates of trait anxiety, CD1 mice were selectively bred for extremes in anxiety-related behavior, with high (HAB) and low (LAB) anxiety-related behavior mice additionally differing in behavioral tests reflecting depression-like behavior. METHODOLOGY/ PRINCIPAL
findingsIn this study, microarray analysis, in situ hybridization, quantitative real-time PCR and immunohistochemistry revealed decreased expression of the vasopressin gene (Avp) in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei of adult LAB mice compared to HAB, NAB (normal anxiety-related behavior) and HABxLAB F1 intercross controls, without detecting differences in receptor expression or density. By sequencing the regions 2.5 kbp up- and downstream of the Avp gene locus, we could identify several polymorphic loci, differing between the HAB and LAB lines. In the gene promoter, a deletion of twelve bp Delta(-2180-2191) is particularly likely to contribute to the reduced Avp expression detected in LAB animals under basal conditions. Indeed, allele-specific transcription analysis of F1 animals revealed a hypomorphic LAB-specific Avp allele with a reduced transcription rate by 75% compared to the HAB-specific allele, thus explaining line-specific Avp expression profiles and phenotypic features. Accordingly, intra-PVN Avp mRNA levels were found to correlate with anxiety-related and depression-like behaviors. In addition to this correlative evidence, a significant, though moderate, genotype/phenotype association was demonstrated in 258 male mice of a freely-segregating F2 panel, suggesting a causal contribution of the Avp promoter deletion to anxiety-related behavior. DISCUSSION: Thus, the identification of polymorphisms in the Avp gene promoter explains gene expression differences in association with the observed phenotype, thus further strengthening the concept of the critical involvement of centrally released AVP in trait anxiety.
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