SynthesisAJNR. American journal of neuroradiology2009
Does diffusion-weighted imaging represent the ischemic core? An evidence-based systematic review.
Synthesis in AJNR. American journal of neuroradiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 128 citations in OpenAlex.
- DWI reversal is associated with small infarct volume in patients with TIA and minor stroke.AJNR. American journal of neuroradiology · 2014Trial
- Automated core-penumbra quantification in neonatal ischemic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Trial
- The infarct core is well represented by the acute diffusion lesion: sustained reversal is infrequent.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Trial
- Mapping DWI signal reversal and long-term tissue outcomes following endovascular therapy in acute ischemic stroke.European radiology · 2026Article
- Significance of Subtle Diffusion Weighted Imaging Lesion Dynamics: A Comparative Analysis of Methods for Detecting Diffusion Weighted Imaging Lesion Reversal in Endovascular Stroke Treatment.Stroke (Hoboken, N.J.) · 2025Article
- Fusion Learning from Non-contrast CT Scans for the Detection of Hemorrhagic Transformation in Stroke Patients.Journal of imaging informatics in medicine · 2025Article
- Reversibility of diffuse magnetic resonance imaging following endovascular therapy in acute ischemic stroke: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2025Article
- Role of Hypoperfusion Intensity Ratio in Vessel Occlusions: A Review on Safety and Clinical Outcomes.AJNR. American journal of neuroradiology · 2025Review
- The fuzzy MAD stroke conjecture, using Fuzzy C Means to classify multimodal apparent diffusion for ischemic stroke lesion stratification.Magnetic resonance imaging · 2025Article
- Article
- MRI of cerebral oedema in ischaemic stroke and its current use in routine clinical practice.Neuroradiology · 2024Review
- Long-Term Effect of Mechanical Thrombectomy in Stroke Patients According to Advanced Imaging Characteristics.Clinical neuroradiology · 2024Article
- Target-based deep learning network surveillance of non-contrast computed tomography for small infarct core of acute ischemic stroke.Frontiers in neurology · 2024Article
- Application of imaging modalities for endovascular thrombectomy of large core infarcts in clinical practice.Frontiers in neurology · 2024Review
- Automated advanced imaging in acute ischemic stroke. Certainties and uncertainties.European journal of radiology open · 2023Article
- Stroke-GFCN: ischemic stroke lesion prediction with a fully convolutional graph network.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- The Vessel Has Been Recanalized: Now What?Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- MRI Radiomics and Predictive Models in Assessing Ischemic Stroke Outcome-A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Neuroimaging of Acute Ischemic Stroke: Multimodal Imaging Approach for Acute Endovascular Therapy.Journal of stroke · 2023Review
- Automated acute ischemic stroke lesion delineation based on apparent diffusion coefficient thresholds.Frontiers in neurology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeDiffusion-weighted(DWI) hyperintensity is hypothesized to represent irreversibly infarcted tissue (ischemic core) in the setting of acute stroke [corrected]. Measurement of the ischemic core has implications for both prognosis and therapy. We wished to assess the level of evidence in the literature supporting this hypothesis. MATERIALS AND
methodsWe performed a systematic review of the literature relating to tissue outcomes of DWI hyperintense stroke lesions in humans. The methodologic rigor of studies was evaluated by using criteria set out by the Oxford Centre for Evidence-Based Medicine. Data from individual studies were also analyzed to determine the prevalence of patients demonstrating lesion progression, no change, or lesion regression compared with follow-up imaging.
resultsLimited numbers of highly methodologically rigorous studies (Oxford levels 1 and 2) were available. There was great variability in observed rates of DWI lesion reversal (0%-83%), with a surprisingly high mean rate of DWI lesion reversal (24% of pooled patients). Many studies did not include sufficient data to determine the precise prevalence of DWI lesion growth or reversal.
conclusionsThe available tissue-outcome evidence supporting the hypothesis that DWI is a surrogate marker for ischemic core in humans is troublingly inconsistent and merits an overall grade D based on the criteria set out by the Oxford Centre for Evidence-Based Medicine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.