ArticleClinical and vaccine immunology : CVI2009
Immunization with oligomannose-coated liposome-entrapped dense granule protein 7 protects dams and offspring from Neospora caninum infection in mice.
Article in Clinical and vaccine immunology : CVI, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Protective efficacy of the NcGRA7-deficient parasite as a live attenuated vaccine against Neospora caninum infection in mice.The Journal of veterinary medical science · 2025Article
- Mitochondrial damage and IL-1β production in monocytes caused byFrontiers in immunology · 2025Article
- Vaccination withVaccines · 2021Article
- Immune Protective Evaluation Elicited by DNA Vaccination WithFrontiers in veterinary science · 2021Article
- Function of Neospora caninum dense granule protein 7 in innate immunity in mice.Parasitology research · 2021Article
- Towards a preventive strategy for neosporosis: challenges and future perspectives for vaccine development against infection with Neospora caninum.The Journal of veterinary medical science · 2017Review
- Immunization with Toxoplasma gondii peroxiredoxin 1 induces protective immunity against toxoplasmosis in mice.PloS one · 2017Article
- Bombyx mori nucleopolyhedrovirus displaying neospora caninum antigens as a vaccine candidate against N. caninum infection in mice.Molecular biotechnology · 2015Article
- Plasmodium berghei circumsporozoite protein encapsulated in oligomannose-coated liposomes confers protection against sporozoite infection in mice.Malaria journal · 2014Article
- Tissue distribution of Neospora caninum in experimentally infected cattle.Clinical and vaccine immunology : CVI · 2013Article
- Oligomannose-coated liposome as a novel adjuvant for the induction of cellular immune responses to control disease status.BioMed research international · 2013Review
- Adjuvant and immunostimulatory effects of a D-galactose-binding lectin from Synadenium carinatum latex (ScLL) in the mouse model of vaccination against neosporosis.Veterinary research · 2012Article
- Preferences for uptake of carbohydrate-coated liposomes by C-type lectin receptors as antigen-uptake receptors.Glycoconjugate journal · 2012Article
- Liposomes and nanotechnology in drug development: focus on oncotargets.International journal of nanomedicine · 2012Article
- Vaccines against a Major Cause of Abortion in Cattle, Neospora caninum Infection.Animals : an open access journal from MDPI · 2011Review
- Recent advancements in cytotoxic T lymphocyte generation methods using carbohydrate-coated liposomes.Journal of biomedicine & biotechnology · 2010Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study demonstrates that the subcutaneous administration of Neospora caninum dense granule protein 7 (NcGRA7) entrapped in liposomes coated with mannotriose strongly induces the parasite-specific T-helper type 1 immune response and humoral antibody in mice. Although anti-NcGRA7 immunoglobulin G1 antibody production was induced in mice injected with NcGRA7 alone, the dams and offspring were never protected from N. caninum infection. The immunization of mice with liposome-entrapped NcGRA7 before pregnancy resulted in increased offspring survival and decreased the infection rates in the brains of dams after parasite infection at 6 to 9 days of gestation. In conclusion, oligomannose-coated liposome-entrapped NcGRA7 can be used as a new type of effective vaccine to control neosporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.