ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Neurogenesis in an adult avian song nucleus is reduced by decreasing caspase-mediated apoptosis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- The Dentate Gyrus Grows Throughout Life Despite Turnover of Developmentally-Born Neurons.Hippocampus · 2026Article
- Seasonal changes in neuronal turnover in a forebrain nucleus in adult songbirds.The Journal of comparative neurology · 2019Article
- Review
- Role of neoblasts in the patterned postembryonic growth of the platyhelminthNeurogenesis (Austin, Tex.) · 2018Article
- Sex Steroids, Adult Neurogenesis, and Inflammation in CNS Homeostasis, Degeneration, and Repair.Frontiers in endocrinology · 2018Review
- Neurogenesis in the adult avian song-control system.Cold Spring Harbor perspectives in biology · 2015Review
- Transsynaptic trophic effects of steroid hormones in an avian model of adult brain plasticity.Frontiers in neuroendocrinology · 2015Review
- Reactive neurogenesis in response to naturally occurring apoptosis in an adult brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Testosterone and brain-derived neurotrophic factor interactions in the avian song control system.Neuroscience · 2013Review
- Article
- Birds as a model to study adult neurogenesis: bridging evolutionary, comparative and neuroethological approaches.The European journal of neuroscience · 2011Review
- Neuroprotective effects of testosterone in a naturally occurring model of neurodegeneration in the adult avian song control system.The Journal of comparative neurology · 2010Article
- Comparative genomic analysis of the zebra finch degradome provides new insights into evolution of proteases in birds and mammals.BMC genomics · 2010Article
- Quantitative analysis of postnatal neurogenesis and neuron number in the macaque monkey dentate gyrus.The European journal of neuroscience · 2010Article
- Turnover of newborn olfactory bulb neurons optimizes olfaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuron death and replacement are fundamental components of brain plasticity. Much remains unknown, however, about the mechanistic interaction between neuron death and neurogenesis in adult vertebrates. In seasonally breeding adult male white-crowned sparrows, the song system nucleus HVC loses approximately 26% of its neurons via caspase-dependent apoptosis within 4 d after a transition to nonbreeding physiological conditions. To determine whether neuronal death is necessary for the recruitment of new neurons, we infused caspase inhibitors into HVC in vivo and suppressed neurodegeneration for at least 20 d after the transition to nonbreeding conditions. The blockade of HVC neuron death reduced the number and density of new neurons recruited to the ipsilateral HVC by 48 and 29%, respectively, compared with contralateral HVC. Our results are the first to show that reducing neuronal death in the adult brain decreases the recruitment of new neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.