ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- Thyrotropin-releasing hormone as a treatment for cancer-related fatigue: a randomized controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012Trial
- Thyrotropin-releasing hormone neurons of different hypothalamic nuclei increase energy expenditure.Nature communications · 2026Article
- Cellular properties and axonal projections of thyrotropin-releasing hormone-expressing neurons in the mouse lateral hypothalamic area.Journal of neurophysiology · 2026Article
- JAK4D, a first-in-class thyrotropin-releasing hormone analogue, reverses scopolamine-induced memory deficits.Brain communications · 2026Article
- Narcolepsy-A Neuropathological Obscure Sleep Disorder: A Narrative Review of Current Literature.Brain sciences · 2022Review
- Origin of thyrotropin-releasing hormone neurons that innervate the tuberomammillary nuclei.Brain structure & function · 2022Article
- Different Peas in the Same Pod: The Histaminergic Neuronal Heterogeneity.Current topics in behavioral neurosciences · 2022Review
- The Role of the Central Histaminergic System in Behavioral State Control.Current topics in behavioral neurosciences · 2022Review
- Biochemical and physiological insights into TRH receptor-mediated signaling.Frontiers in cell and developmental biology · 2022Review
- Article
- Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection.Neural plasticity · 2018Review
- Article
- Unmet needs of patients with narcolepsy: perspectives on emerging treatment options.Nature and science of sleep · 2015Review
- Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Acid-sensing hypothalamic neurons controlling arousal.Cellular and molecular neurobiology · 2014Review
- Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord.The Journal of physiology · 2014Article
- Brain regulation of energy balance and body weight.Reviews in endocrine & metabolic disorders · 2013Review
- Benzodiazepine-site pharmacology on GABAA receptors in histaminergic neurons.British journal of pharmacology · 2013Article
- Hypothyroidism compromises hypothalamic leptin signaling in mice.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Thyrotropin-releasing hormone-containing axons innervate histaminergic neurons in the tuberomammillary nucleus.Brain research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The histaminergic tuberomamillary nucleus (TMN) controls arousal and attention, and the firing of TMN neurons is state-dependent, active during waking, silent during sleep. Thyrotropin-releasing hormone (TRH) promotes arousal and combats sleepiness associated with narcolepsy. Single-cell reverse-transcription-PCR demonstrated variable expression of the two known TRH receptors in the majority of TMN neurons. TRH increased the firing rate of most (ca 70%) TMN neurons. This excitation was abolished by the TRH receptor antagonist chlordiazepoxide (CDZ; 50 mum). In the presence of tetrodotoxin (TTX), TRH depolarized TMN neurons without obvious change of their input resistance. This effect reversed at the potential typical for nonselective cation channels. The potassium channel blockers barium and cesium did not influence the TRH-induced depolarization. TRH effects were antagonized by inhibitors of the Na(+)/Ca(2+) exchanger, KB-R7943 and benzamil. The frequency of GABAergic spontaneous IPSCs was either increased (TTX-insensitive) or decreased [TTX-sensitive spontaneous IPSCs (sIPSCs)] by TRH, indicating a heterogeneous modulation of GABAergic inputs by TRH. Facilitation but not depression of sIPSC frequency by TRH was missing in the presence of the kappa-opioid receptor antagonist nor-binaltorphimine. Montirelin (TRH analog, 1 mg/kg, i.p.) induced waking in wild-type mice but not in histidine decarboxylase knock-out mice lacking histamine. Inhibition of histamine synthesis by (S)-alpha-fluoromethylhistidine blocked the arousal effect of montirelin in wild-type mice. We conclude that direct receptor-mediated excitation of rodent TMN neurons by TRH demands activation of nonselective cation channels as well as electrogenic Na(+)/Ca(2+) exchange. Our findings indicate a key role of the brain histamine system in TRH-induced arousal.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.