ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2009
Adenosine 2B receptors (A(2B)AR) on enteric neurons regulate murine distal colonic motility.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Purinergic signaling in the gut neuro-glial-immune axis: mechanisms of homeostasis, inflammation, and gastrointestinal dysfunction.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.Cell · 2023Article
- C/EBPβ/AEP is age-dependently activated in Parkinson's disease and mediates α-synuclein in the gut and brain.NPJ Parkinson's disease · 2023Article
- Molecular Characterization of Constipation Disease as Novel Phenotypes in CRISPR-Cas9-Generated Leptin Knockout Mice with Obesity.International journal of molecular sciences · 2020Article
- Intestinal Bacteria Maintain Adult Enteric Nervous System and Nitrergic Neurons via Toll-like Receptor 2-induced Neurogenesis in Mice.Gastroenterology · 2020Article
- Initiation of Parkinson's disease from gut to brain by δ-secretase.Cell research · 2020Article
- Interactions Between Commensal Bacteria and Enteric Neurons, via FPR1 Induction of ROS, Increase Gastrointestinal Motility in Mice.Gastroenterology · 2019Article
- Colonic motor dysfunctions in a mouse model of high-fat diet-induced obesity: an involvement of APurinergic signalling · 2017Article
- Adenosine AJournal of clinical medicine · 2017Review
- SMV1, an extremely stable thermophilic virus platform for nanoparticle trafficking in the mammalian GI tract.Journal of applied microbiology · 2017Article
- Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome.Scientific reports · 2017Article
- Intestinal dysbiosis contributes to the delayed gastrointestinal transit in high-fat diet fed mice.Cellular and molecular gastroenterology and hepatology · 2016Article
- Potential for developing purinergic drugs for gastrointestinal diseases.Inflammatory bowel diseases · 2014Review
- Role of the A(2B) receptor-adenosine deaminase complex in colonic dysmotility associated with bowel inflammation in rats.British journal of pharmacology · 2014Article
- Tumor necrosis factor-neuropeptide Y cross talk regulates inflammation, epithelial barrier functions, and colonic motility.Inflammatory bowel diseases · 2013Article
- Article
- Novel functional roles for enteric glia in the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2012Review
- Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling.Gastroenterology · 2012Article
- Adenosine negatively regulates duodenal motility in mice: role of A(1) and A(2A) receptors.British journal of pharmacology · 2011Article
- Impact of disrupting adenosine A₃ receptors (A₃⁻/⁻ AR) on colonic motility or progression of colitis in the mouse.Inflammatory bowel diseases · 2011Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Delayed colonic emptying leading to constipation is a significant health concern. We investigated the role of adenosine 2B receptor (A(2B)AR) in modulating distal colonic motility using wild-type and A(2B)AR-knockout (A(2B)AR(-/-)) mice. Colon motility was assessed using stool characteristics and colonic transit. Distal colonic ganglia, isolated by laser capture microdissection, were tested for A(2B)AR expression by RT-PCR. The distal colon contraction and relaxation responses were assessed by electrical field stimulation (EFS) in presence of A(2B)AR agonists, antagonists or inhibitors of nitric oxide (NO) and guanylate cyclase. Nitrite levels were measured in enteric neuronal cultures exposed to A(2B)AR agonists/antagonists. A(2B)AR(-/-) mice display increased stool retention, decreased stool frequency, delayed colonic emptying, and decreased circular muscle relaxation. RT-PCR identified A(2B)AR expression in distal colonic ganglia. EFS studies revealed that enteric neuronal A(2B)AR is essential for distal colonic relaxation, and A(2B)AR antagonists can inhibit relaxation. Enteric neurons stimulated with A(2B)AR agonists produced more nitrite than cultures treated with antagonists. We demonstrate an essential role of A(2B)AR in regulating distal colon relaxation, as A(2B)AR activation is linked to NO signaling. Hence targeting the colonic A(2B)AR could represent a novel therapeutic strategy to treat constipation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.