ArticleToxicological sciences : an official journal of the Society of Toxicology2009
A toxicology for the 21st century--mapping the road ahead.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Closing the gap between in vivo and in vitro omics: using QA/QC to strengthen ex vivo NMR metabolomics.NMR in biomedicine · 2023Review
- A continuous in silico learning strategy to identify safety liabilities in compounds used in the leather and textile industry.Archives of toxicology · 2023Article
- Advanced lung organoids and lung-on-a-chip for cancer research and drug evaluation: a review.Frontiers in bioengineering and biotechnology · 2023Review
- Biomimetic lung-on-a-chip to model virus infection and drug evaluation.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2023Review
- Grouping of chemicals into mode of action classes by automated effect pattern analysis using the zebrafish embryo toxicity test.Archives of toxicology · 2022Article
- Human biomimetic liver microphysiology systems in drug development and precision medicine.Nature reviews. Gastroenterology & hepatology · 2021Review
- Time-dependent behavioral data from zebrafish reveals novel signatures of chemical toxicity using point of departure analysis.Computational toxicology (Amsterdam, Netherlands) · 2019Article
- The future of skin toxicology testing - Three-dimensional bioprinting meets microfluidics.International journal of bioprinting · 2019Article
- Perspectives onApplied in vitro toxicology · 2018Review
- Has Toxicity Testing Moved into the 21st Century? A Survey and Analysis of Perceptions in the Field of Toxicology.Environmental health perspectives · 2017Article
- 21st Century Cell Culture for 21st Century Toxicology.Chemical research in toxicology · 2017Article
- FutureTox III: Bridges for Translation.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Probabilistic hazard assessment for skin sensitization potency by dose-response modeling using feature elimination instead of quantitative structure-activity relationships.Journal of applied toxicology : JAT · 2015Article
- The human toxome project.ALTEX · 2015Article
- Mapping the human toxome by systems toxicology.Basic & clinical pharmacology & toxicology · 2014Review
- Pathways of Toxicity.ALTEX · 2014Article
- Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities.ALTEX · 2014Review
- Perspectives of the development strategies for a future toxicity testing system in China: challenges and opportunities.Environmental health perspectives · 2013Article
- Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.ALTEX · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The landmark publication by the National Research Council putting forward a vision of a toxicology for the 21st century in 2007 has created an atmosphere of departure in our field. The alliances formed, symposia and meetings held and the articles following are remarkable, indicating that this is an idea whose time has come. Most of the discussion centers on the technical opportunities to map pathways of toxicity and the financing of the program. Here, the other part of the work ahead shall be discussed, that is, the focus is on regulatory implementation once the technological challenges are managed, but we are well aware that the technical aspects of what the National Academy of Science report suggests still need to be addressed: A series of challenges are put forward which we will face in addition to finding a technical solution (and its funding) to set this vision into practice. This includes the standardization and quality assurance of novel methodologies, their formal validation, their integration into test strategies including threshold setting and finally a global acceptance and implementation. This will require intense conceptual steering to have all pieces of the puzzle come together.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.