ArticleCellular immunology2009
Lethal pulmonary infection with Francisella novicida causes depletion of alphabeta T cells from lungs.
Article in Cellular immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Function of SLAM-Associated Protein (SAP) in Acute Pneumoseptic Bacterial Infection.Journal of molecular biology · 2019Review
- Article
- Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia.PloS one · 2013Article
- Vaccination with an attenuated strain of Francisella novicida prevents T-cell depletion and protects mice infected with the wild-type strain from severe sepsis.Infection and immunity · 2009Article
- Features of sepsis caused by pulmonary infection with Francisella tularensis Type A strain.Microbial pathogenesisArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Respiratory Francisella infections induce a delayed innate immune response followed by a severe sepsis like condition. In this study, mice infected intranasally with Francisella novicida showed a depletion of alphabeta T cells in lungs while exhibiting large accumulations of other leukocytes correlating with disease severity. The depleted T cells were predominantly CD4(+). The alphabeta T cells in infected mice showed significantly higher levels of Annexin V binding than those in mock control mice suggesting increased apoptosis of T cells. These results suggest that lack of transition from an innate to adaptive host response is associated with lethality of respiratory tularemia.
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Registered trials
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