Evidence map›Paper›PMID 19356074›Full record

ArticleDrug metabolism letters2008

Effect of folic acid on methotrexate induction of sulfotransferases in rats.

Sangita Maiti Dutta, Smarajit Maiti, Guangping Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Sangita Maiti DuttaDepartment of Physiological Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Smarajit Maiti
Guangping Chen
Oklahoma State University · USOklahoma State University Oklahoma City · US

Funding

Mechanisms and Functions of Human SulfotransferasesR01GM078606 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI CHEN, GUANGPING · 2006 to 2009
$1.1M
NIGMS NIH HHS GM 078606NIGMS NIH HHS R01 GM078606
6 · The paper itself

Abstract

Our earlier investigation showed that MTX is an inducer of rat and human sulfotransferases. Here we report that folic acid treatment inhibited MTX induction of aryl sulfotransferase (AST-IV) in female rat liver and hydroxysteroid sulfotransferase (STa) in male rat liver. This is important for understanding the clinical mechanisms of MTX.

Indexed as

AnimalsAntimetabolites, AntineoplasticArylsulfotransferaseDrug InteractionsEnzyme InductionFemaleFolic AcidGene Expression RegulationLiverMaleMethotrexateRatsRats, Sprague-DawleyRNA, MessengerSex FactorsSulfotransferasesalcohol sulfotransferaseAntimetabolites, AntineoplasticArylsulfotransferaseFolic AcidMethotrexateRNA, MessengerSulfotransferases

Identifiers

PMID19356074
PMCPMC3108250
OpenAlexW2135059499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.