ReviewMetabolic syndrome and related disorders2009
Human immunodeficiency virus and highly active antiretroviral therapy-associated metabolic disorders and risk factors for cardiovascular disease.
Review in Metabolic syndrome and related disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 62 citations in OpenAlex.
- Substituting Abacavir for Stavudine in Children Who Are Virally Suppressed Without Lipodystrophy: Randomized Clinical Trial in Johannesburg, South Africa.Journal of the Pediatric Infectious Diseases Society · 2018Trial
- A home-based exercise intervention to increase physical activity among people living with HIV: study design of a randomized clinical trial.BMC public health · 2013Trial
- High prevalence of impaired glucose metabolism among children and adolescents living with HIV in Ghana.HIV medicine · 2024Article
- Early Inflammatory Signatures Predict Subsequent Cognition in Long-Term Virally Suppressed Women With HIV.Frontiers in integrative neuroscience · 2020Article
- Comorbidities and polypharmacy among HIV-positive patients aged 50 years and over: a case-control study.BMC research notes · 2019Article
- Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study.Journal of lipid research · 2018Article
- The effect of aerobic exercises on lipid profile of patients with human immunodeficiency virus infection undergoing highly active antiretroviral therapy: a protocol for a systematic review.Journal of exercise rehabilitation · 2018Review
- Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic.Toxicological sciences : an official journal of the Society of Toxicology · 2018Review
- Insulin Resistance in HIV-Patients: Causes and Consequences.Frontiers in endocrinology · 2018Review
- Yield of yearly routine physical examination in HIV-1 infected patients is limited: A retrospective cohort study in the Netherlands.PloS one · 2017Article
- Complement Component 3 Is Associated with Metabolic Comorbidities in Older HIV-Positive Adults.AIDS research and human retroviruses · 2016Observational
- Exercise therapy for human immunodeficiency virus/AIDS patients: Guidelines for clinical exercise therapists.Journal of exercise science and fitness · 2015Review
- Antiretroviral therapy-induced lipodystrophy.BMJ case reports · 2015Article
- Designer adiponectin receptor agonist stabilizes metabolic function and prevents brain injury caused by HIV protease inhibitors.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Article
- HIV disease activity as a modulator of lipoprotein(a) and allele-specific apolipoprotein(a) levels.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Brain injury caused by HIV protease inhibitors: role of lipodystrophy and insulin resistance.Antiviral research · 2012Article
- Macrophage endocytic trafficking of antiretroviral nanoparticles.Nanomedicine (London, England) · 2011Article
- Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation.AIDS research and therapy · 2010Article
- Metabolic and neurologic consequences of chronic lopinavir/ritonavir administration to C57BL/6 mice.Antiviral research · 2010Article
- Health Benefits of Exercise for People Living With HIV: A Review of the Literature.American journal of lifestyle medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The successful introduction of highly active antiretroviral therapy (HAART), a combination of potent antiretroviral agents, including protease inhibitors, nucleoside reverse transcriptase inhibitors, and nonnucleoside reverse transcriptase inhibitors, has impacted positively on morbidity and mortality among human immunodeficiency virus (HIV)-positive patients. Over time, HAART has been associated with a number of metabolic and anthropometric abnormalities, including dyslipidemia and insulin resistance as well as subcutaneous fat loss and abdominal obesity, potentially contributing to cardiovascular risk. Recent studies have more firmly established that both HIV infection and HAART might increase the risk of clinical cardiovascular events. Furthermore, whereas HIV/HAART is associated with multiple aspects of endocrine dysfunction, there has been less focus on bone disease, although some studies indicate a higher prevalence of osteoporosis among HIV-positive subjects compared to HIV-negative controls. The relationship between bone and fat metabolism under HIV-positive conditions deserves further attention, and available data suggest the possibility of an intriguing connection. In the future, an increasing population of aging HIV-positive patients with a spectrum of antiretroviral therapies and accumulation of endocrine abnormalities and conventional cardiovascular risk factors will present preventive and therapeutic challenges to our health-care system.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.