ArticleMagnetic resonance in medicine2009
Temporal changes in the T1 and T2 relaxation rates (DeltaR1 and DeltaR2) in the rat brain are consistent with the tissue-clearance rates of elemental manganese.
Article in Magnetic resonance in medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 60 citations in OpenAlex.
- Quality Assurance Strategies for Brain State Characterization by MEMRI.bioRxiv : the preprint server for biology · 2026Article
- The role of quantitative T1 and T2 mapping for detecting minimal hepatic encephalopathy in chronic hepatic schistosomiasis patients.PloS one · 2026Observational
- Genetic control of MRI contrast using the manganese transporter Zip14.Magnetic resonance in medicine · 2024Article
- In vivo MRI evaluation of anterograde manganese transport along the visual pathway following whole eye transplantation.Journal of neuroscience methods · 2022Article
- Chronic Intestinal Inflammation Suppresses Brain Activity by Inducing Neuroinflammation in Mice.The American journal of pathology · 2022Article
- Activity-induced MEMRI cannot detect functional brain anomalies in the APPxPS1-Ki mouse model of Alzheimer's disease.Scientific reports · 2019Article
- Applications of Manganese-Enhanced Magnetic Resonance Imaging in Ophthalmology and Visual Neuroscience.Frontiers in neural circuits · 2019Review
- Plasticity changes in forebrain activity and functional connectivity during neuropathic pain development in rats with sciatic spared nerve injury.Molecular brain · 2018Article
- Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity.Brain structure & function · 2018Article
- Development of manganese-enhanced magnetic resonance imaging of the rostral ventrolateral medulla of conscious rats: Importance of normalization and comparison with other regions of interest.NMR in biomedicine · 2018Article
- Thalamic GABA levels and occupational manganese neurotoxicity: Association with exposure levels and brain MRI.Neurotoxicology · 2018Article
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- Manganese-Enhanced Magnetic Resonance Imaging and Studies of Rat Behavior: Transient Motor Deficit in Skilled Reaching, Rears, and Activity in Rats After a Single Dose of MnClMagnetic resonance insights · 2017Article
- Uptake and retention of manganese contrast agents for PET and MRI in the rodent brain.Contrast media & molecular imaging · 2016Article
- Manganese-Enhanced Magnetic Resonance Imaging as a Diagnostic and Dispositional Tool after Mild-Moderate Blast Traumatic Brain Injury.Journal of neurotrauma · 2016Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation.NeuroImage · 2016Article
- Cocaine-induced locomotor sensitization in rats correlates with nucleus accumbens activity on manganese-enhanced MRI.NMR in biomedicine · 2015Article
- Potential of N-acetylated-para-aminosalicylic acid to accelerate manganese enhancement decline for long-term MEMRI in rodent brain.Journal of neuroscience methods · 2015Article
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3 authors at 3 institutions in 1 country.
Funding
Abstract
Temporal changes in the T(1) and T(2) relaxation rates (DeltaR(1) and DeltaR(2)) in rat olfactory bulb (OB) and cortex were compared with the absolute manganese (Mn) concentrations from the corresponding excised tissue samples. In vivo T(1) and T(2) relaxation times were measured before, and at 1, 7, 28, and 35 d after intravenous infusion of 176 mg/kg MnCl(2). The values of DeltaR(1), DeltaR(2), and absolute Mn concentration peaked at day 1 and then declined to near control levels after 28 to 35 d. The Mn bioelimination rate from the rat brain was significantly faster than that reported using radioisotope techniques. The R(1) and R(2) relaxation rates were linearly proportional to the underlying tissue Mn concentration and reflect the total absolute amount of Mn present in the tissue. The in vivo Mn r(1) and r(2) tissue relaxivities were comparable to the in vitro values for aqueous Mn(2+). These results demonstrate that loss of manganese-enhanced MRI (MEMRI) contrast after systemic Mn(2+) administration is due to elimination of Mn(2+) from the brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.