ArticleJournal of biomedical materials research. Part A2010
Enhanced polarization of embryonic hippocampal neurons on micron scale electrospun fibers.
Article in Journal of biomedical materials research. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Electrospun decellularized extracellular matrix scaffolds promote the regeneration of injured neurons.Biomaterials and biosystems · 2023Article
- Directional Submicrofiber Hydrogel Composite Scaffolds Supporting Neuron Differentiation and Enabling Neurite Alignment.International journal of molecular sciences · 2022Article
- Controlling the Spatiotemporal Release of Nerve Growth Factor by Chitosan/Polycaprolactone Conduits for Use in Peripheral Nerve Regeneration.International journal of molecular sciences · 2022Article
- Understanding, engineering, and modulating the growth of neural networks: An interdisciplinary approach.Biophysics reviews · 2021Review
- An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering.Advanced functional materials · 2020Article
- Investigation of neuronal pathfinding and construction of artificial neuronal networks on 3D-arranged porous fibrillar scaffolds with controlled geometry.Scientific reports · 2017Article
- Intracellular calcium and cyclic nucleotide levels modulate neurite guidance by microtopographical substrate features.Journal of biomedical materials research. Part A · 2016Article
- Mechanotransduction of Neural Cells Through Cell-Substrate Interactions.Tissue engineering. Part B, Reviews · 2016Review
- Neuronal electrophysiological function and control of neurite outgrowth on electrospun polymer nanofibers are cell type dependent.Tissue engineering. Part A · 2014Article
- Tissue engineering the retinal ganglion cell nerve fiber layer.Biomaterials · 2013Article
- Article
- Combining topographical and genetic cues to promote neuronal fate specification in stem cells.Biomacromolecules · 2012Review
- Aligned electrospun scaffolds and elastogenic factors for vascular cell-mediated elastic matrix assembly.Journal of tissue engineering and regenerative medicine · 2012Article
- Development of channeled nanofibrous scaffolds for oriented tissue engineering.Macromolecular bioscience · 2012Article
- BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice.Scientific reports · 2012Article
- Selective axonal growth of embryonic hippocampal neurons according to topographic features of various sizes and shapes.International journal of nanomedicine · 2010Article
- Hippocampal neurons respond uniquely to topographies of various sizes and shapes.Biofabrication · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Electrospun fibers have been fabricated for wide use as artificial tissue engineering scaffolds. In particular, fibers smaller than a cell body have been extensively employed to mimic natural extracellular matrix (ECM) and to explore specific responses by various cell types. We investigated the effects of various poly(lactic acid-co-glycolic acid) (PLGA) fiber features on embryonic hippocampal neurons in the early developmental stages in terms of initial axon formation (i.e., polarization) and axon orientation. We produced PLGA fibers that have average diameters ranging from 0.44 microm to 2.2 microm and different degrees of fiber alignment (16-58 degrees in angular standard deviation). After 22 h in culture, embryonic hippocampal neurons grown on PLGA fibers exhibited more axon formation with a 30-50% increase over those on spin-coated smooth PLGA films. This improvement was independent of fiber diameter and alignment; however, slightly more polarization was observed on the smaller fibers and the more aligned fibers. In addition, average axon length of the polarized embryonic hippocampal neurons was not significantly different among the PLGA fibers when compared with cells grown on spin-coated PLGA films. These findings suggest that fibers of subcellular diameters stimulate initial axon establishment and guide the direction of axonal extension; however, these fibers do not appear to affect the overall axon length. This information will be valuable in understanding the roles of subcellular features on neuron development and for the design of biomaterials for neural tissue interfacing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.