ArticlePloS one2009
A complex cell division machinery was present in the last common ancestor of eukaryotes.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Reconstructing the last common ancestor of all eukaryotes.PLoS biology · 2024Review
- Midbody-Localized Aquaporin Mediates Intercellular Lumen Expansion During Early Cleavage of an Invasive Freshwater Bivalve.Frontiers in cell and developmental biology · 2022Article
- Comparative genomics of nuclear envelope proteins.BMC genomics · 2018Article
- Archaea and the origin of eukaryotes.Nature reviews. Microbiology · 2017Review
- Extreme genome diversity in the hyper-prevalent parasitic eukaryote Blastocystis.PLoS biology · 2017Article
- The multiple evolutionary origins of the eukaryotic N-glycosylation pathway.Biology direct · 2016Article
- Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns.BMC evolutionary biology · 2015Article
- Origin and evolution of the self-organizing cytoskeleton in the network of eukaryotic organelles.Cold Spring Harbor perspectives in biology · 2014Review
- Alternative cytoskeletal landscapes: cytoskeletal novelty and evolution in basal excavate protists.Current opinion in cell biology · 2013Review
- The phylogenomic analysis of the anaphase promoting complex and its targets points to complex and modern-like control of the cell cycle in the last common ancestor of eukaryotes.BMC evolutionary biology · 2011Article
- Strong functional patterns in the evolution of eukaryotic genomes revealed by the reconstruction of ancestral protein domain repertoires.Genome biology · 2011Article
- Comparative genomic evidence for a complete nuclear pore complex in the last eukaryotic common ancestor.PloS one · 2010Article
- The origin of eukaryotes and their relationship with the Archaea: are we at a phylogenomic impasse?Nature reviews. Microbiology · 2010Review
- Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature.Genome biology and evolution · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe midbody is a transient complex structure containing proteins involved in cytokinesis. Up to now, it has been described only in Metazoa. Other eukaryotes present a variety of structures implied in the last steps of cell division, such as the septum in fungi or the phragmoplast in plants. However, it is unclear whether these structures are homologous (derive from a common ancestral structure) or analogous (have distinct evolutionary origins). Recently, the proteome of the hamster midbody has been characterized and 160 proteins identified. METHODOLOGY/PRINCIPAL
findingsUsing phylogenomic approaches, we show here that nearly all of these 160 proteins (95%) are conserved across metazoan lineages. More surprisingly, we show that a large part of the mammalian midbody components (91 proteins) were already present in the last common ancestor of all eukaryotes (LECA) and were most likely involved in the construction of a complex multi-protein assemblage acting in cell division. CONCLUSIONS/SIGNIFICANCE: Our results indicate that the midbodies of non-mammalian metazoa are likely very similar to the mammalian one and that the ancestor of Metazoa possessed a nearly modern midbody. Moreover, our analyses support the hypothesis that the midbody and the structures involved in cytokinesis in other eukaryotes derive from a large and complex structure present in LECA, likely involved in cytokinesis. This is an additional argument in favour of the idea of a complex ancestor for all contemporary eukaryotes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.