ArticleThe American journal of gastroenterology2009
Statins and the risk of colorectal carcinoma: a nested case-control study in veterans with diabetes.
Article in The American journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Statins and the risk of colorectal cancer: an updated systematic review and meta-analysis of 40 studies.World journal of gastroenterology · 2014Pooled it
- Statins and the Risk of Colorectal Cancer in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.Gastroenterology research · 2025Article
- Statins and Colorectal Cancer Risk: A Population-Based Case-Control Study and Synthesis of the Epidemiological Evidence.Journal of clinical medicine · 2022Article
- Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism.BMC cancer · 2021Article
- Article
- Statin Use and Cancer Incidence in Patients with Type 2 Diabetes Mellitus: A Network Meta-Analysis.Gastroenterology research and practice · 2018Review
- Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells.Gut and liver · 2016Article
- Lung and colorectal cancer treatment and outcomes in the Veterans Affairs health care system.Cancer management and research · 2015Review
- Chemopreventive drugs: mechanisms via inhibition of cancer stem cells in colorectal cancer.World journal of gastroenterology · 2014Review
- Beyond aspirin-cancer prevention with statins, metformin and bisphosphonates.Nature reviews. Clinical oncology · 2013Review
- Statin use is associated with a reduced incidence of colorectal adenomatous polyps.International journal of colorectal disease · 2013Article
- BAYESIAN SEMIPARAMETRIC ANALYSIS FOR TWO-PHASE STUDIES OF GENE-ENVIRONMENT INTERACTION.The annals of applied statistics · 2013Article
- Statins and colorectal cancer.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2013Review
- Statins and the risk of gastric cancer in diabetes patients.BMC cancer · 2012Article
- Statin use is associated with a reduced incidence of colorectal cancer: a colonoscopy-controlled case-control study.BMC gastroenterology · 2012Article
- Statin use and the risk of colorectal cancer: a population-based case-control study.World journal of gastroenterology · 2011Article
- Statin adherence and the risk of major coronary events in patients with diabetes: a nested case-control study.British journal of clinical pharmacology · 2011Article
- Article
- Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms.World journal of gastroenterology · 2011Review
- Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesExperimental data indicate a possible preventive effect for statins in colorectal cancer (CRC). However, the available epidemiological data are conflicting.
methodsWe conducted a nested case-control study of veterans with diabetes in national databases of the Department of Veterans Affairs (VA) and Medicare-linked files. Cases were defined as incident CRC during January 2001-December 2002, sampled on incidence density. VA pharmacy benefits management (PBM) files were used to identify filled prescriptions for statins. Multivariable conditional logistic regression models were used to estimate odds ratios (ORs) after adjusting for potential confounding variables. Stratified analyses were conducted for potential effect modifiers.
resultsA total of 6,080 cases and 24,320 controls were examined. The mean age was 74 years, and the majority of patients were Caucasian (88%) and male (99%). Filled prescriptions of statins were recorded less frequently in cases (49%) than in controls (52%; OR: 0.88; 95% confidence interval (95% CI): 0.83-0.93). This inverse association remained significant after adjusting for inflammatory bowel disease, diabetes severity, cholecystectomy, liver disease, filled prescriptions for sulfonylurea, aspirin or NSAID use, or colorectal evaluation. Simvastatin comprised the majority (87%) of statin-filled prescriptions, and the association with risk of CRC with simvastatin was very similar to that of any statin. No significant associations were observed between the risk of CRC and nonstatin cholesterol (OR: 1.02; 95% CI 0.88-1.18) or triglyceride-lowering medications (OR: 0.96; 95% CI: 0.87-1.05). The significant inverse association was limited to Caucasians, patients without history of polyps, patients aged 65 years and older, and patients with colon cancer (excluding rectum).
conclusionsThe use of statins was associated with a small reduction in the risk of colon cancer in patients with diabetes. However, the causal link is not clear.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.