Evidence map›Paper›PMID 19352177›Full record

ReviewCurrent opinion in nephrology and hypertension2009

Phosphate sensing.

Rajiv Kumar

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in nephrology and hypertension, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Review
  3. Under-recognized Hypoparathyroidism in ThalassemiaJournal of clinical research in pediatric endocrinology · 2018
    Article
  4. Phosphate (PThe Journal of biological chemistry · 2018
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Increased renal dopamine and acute renal adaptation to a high-phosphate diet.American journal of physiology. Renal physiology · 2011
    Article
  11. Review
  12. Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro.Matrix biology : journal of the International Society for Matrix Biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Rajiv KumarDepartments of Medicine, Biochemistry and Molecular Biology, Division of Nephrology and Hypertension, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. rkumar@mayo.edu
Mayo Clinic · US

Funding

REGULATIOIN OF RENAL PHOSPHATE EXCRETION AND VITAMIN D METABOLISM BY FGF 7R01DK076829 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV · 2007 to 2010
$1.2M
Biology of a Novel Phosphaturic Protein - sFRP-4R01DK065830 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV · 2004 to 2007
$1.2M
Hyperoxaluria and Nephrolithiasis After Gastric Bypass Surgery for ObesityR21DK077669 · NIDDK · MAYO CLINIC ROCHESTER · PI KUMAR, RAJIV · 2007 to 2008
$412k
NIDDK NIH HHS DK 65830NIDDK NIH HHS DK 76829NIDDK NIH HHS DK 77669NIDDK NIH HHS R01 DK065830NIDDK NIH HHS R01 DK076829NIDDK NIH HHS R21 DK077669
6 · The paper itself

Abstract

purpose of reviewTo discuss findings suggesting the presence of a phosphate-sensing mechanism in the various organs and the presence of a novel intestinal effector that alters renal phosphate excretion after the ingestion of a phosphate-containing meal. RECENT

findingsAlthough phosphate homeostasis is controlled by a variety of hormones (such as parathyroid hormone and 1,25-dihydroxyvitamin D), peptides (the phosphatonins - fibroblast growth factor 23, secreted frizzled-related protein-4, matrix extracellular phosphoglycoprotein) and small molecules (dopamine) that regulate the efficiency of phosphate absorption in the intestine and phosphate excretion in the renal tubule, recent data suggest that postcibal changes in renal phosphate excretion following a meal containing phosphate are mediated by signals generated within the intestine that alter the efficiency of phosphate excretion in the kidney. The intestine detects luminal phosphate and signals to the kidney via the release of the mediator that increases renal phosphate excretion. SUMMARY: Such information would imply the existence of a phosphate-sensing mechanism within the intestine and the presence of intestinal factors that influence renal phosphate handling.

Indexed as

AnimalsHomeostasisHumansIntestinal MucosaKidneyParathyroid HormonePhosphatesParathyroid HormonePhosphates

Identifiers

PMID19352177
PMCPMC2872784
OpenAlexW4251293220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.