ArticleJAMA2009
Persistent chest pain and no obstructive coronary artery disease.
Article in JAMA, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02910154 (Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower Cohort), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower Cohort
Who cites it
30 citing papers in PubMed, 80 citations in OpenAlex.
- Trial
- Microvascular coronary artery spasm presents distinctive clinical features with endothelial dysfunction as nonobstructive coronary artery disease.Journal of the American Heart Association · 2012Trial
- Improvement in health-related quality of life after therapy with omeprazole in patients with coronary artery disease and recurrent angina-like chest pain. A double-blind, placebo-controlled trial of the SF-36 survey.Health and quality of life outcomes · 2011Trial
- Effect of Premature Acute Coronary Syndrome on Ocular Hemodynamics.International journal of medical sciences · 2025Article
- Transcriptomic and spatial dissection of human ex vivo right atrial tissue reveals proinflammatory microvascular changes in ischemic heart disease.Cell reports. Medicine · 2024Article
- Coronary Vascular (DYS) Function and Invasive Physiology Assessment: Insights into Bolus and Continuous Thermodilution Methods.Journal of clinical medicine · 2023Review
- 2023 Guidelines of the Taiwan Society of Cardiology on the Diagnosis and Management of Chronic Coronary Syndrome.Acta Cardiologica Sinica · 2023Article
- A Practical Approach to Invasive Testing in Ischemia With No Obstructive Coronary Arteries (INOCA).CJC open · 2022Review
- Microvascular Angina: Diagnosis and Management.European cardiology · 2021Review
- Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease.Cardiovascular intervention and therapeutics · 2021Review
- Outpatient Management of Patients With Angina With No Obstructive Coronary Arteries: How to Come to a Proper Diagnosis and Therapy.Frontiers in cardiovascular medicine · 2021Review
- Echocardiographic measurement of epicardial adipose tissue thickness in patients with microvascular angina.Interventional medicine & applied science · 2019Article
- Coronary microvascular dysfunction is associated with poor glycemic control amongst female diabetics with chest pain and non-obstructive coronary artery disease.Cardiovascular diabetology · 2019Article
- Women's health: making cardiovascular disease real.Current opinion in cardiology · 2018Review
- False-positive stress testing: Does endothelial vascular dysfunction contribute to ST-segment depression in women? A pilot study.Clinical cardiology · 2018Article
- Evaluation of the coronary flow by the coronary clearance time in patients with cardiac syndrome X.The Journal of international medical research · 2018Article
- Sex as a Biological Variable in Emergency Medicine Research and Clinical Practice: A Brief Narrative Review.The western journal of emergency medicine · 2017Review
- Coronary Microvascular Dysfunction - Epidemiology, Pathogenesis, Prognosis, Diagnosis, Risk Factors and Therapy.Circulation journal : official journal of the Japanese Circulation Society · 2016Review
- The role of cardiac CT in women.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Review
- Women and Chest Pain: Recognizing the Different Faces of Angina in the Emergency Department.The Yale journal of biology and medicine · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Patients with persistent chest pain and no obstructive coronary artery disease are often labeled as having noncardiac pain and not offered further cardiologic testing or treatment. Diagnostic uncertainty for persistent chest pain is associated with adverse quality of life, morbidity, and health care costs. Two underdiagnosed cardiac causes for persistent chest pain include microvascular coronary disease and abnormal cardiac nociception. Microvascular coronary disease is associated with an increased risk of adverse cardiovascular events such as myocardial infarction, congestive heart failure, and sudden cardiac death, and treatment directed at improving endothelial function can improve outcomes. Abnormal cardiac nociception is also a cause for persistent chest pain caused by heightened coronary pain perception. Coronary reactivity testing allows for direct measurement of blood flow characteristics in response to vasoactive agents for the diagnoses of microvascular coronary disease and can be a useful tool to differentiate causes of chest pain. Coronary reactivity testing is an invasive method for assessing coronary vascular function, with current evidence suggesting that its associated risk is relatively low compared with the adverse prognosis associated with microvascular coronary dysfunction. Accurate diagnosis in patients with persistent chest pain and normal coronary arteries can be challenging and deserves adequate investigation in light of the associated morbidity, mortality, and health care costs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.