Evidence map›Paper›PMID 19351775›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2009

CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy.

Kathleen M Sakamoto, David A Frank

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 171 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 1 synthesis or guideline pooled it, 290 citations in OpenAlex.

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  20. Cyclic AMP-regulatory element-binding protein: a novel UV-targeted transcription factor in skin cancer.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2024
    Review

111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kathleen M SakamotoDivision of Hematology-Oncology, Gwynne Hazen Cherry Memorial Laboratories, Mattel Children's Hospital UCLA, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
David A Frank
Harvard University · USUniversity of California, Los Angeles · US

Funding

The Role of CREB in Normal Myelopoiesis and LeukemogenesisR01HL075826 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAKAMOTO, KATHLEEN M · 2004 to 2013
$3.2M
Molecular and Cellular Characterization of Myeloproliferative DiseaseR01HL083077 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAKAMOTO, KATHLEEN M · 2005 to 2010
$1.5M
NHLBI NIH HHS HL75826NHLBI NIH HHS HL83077NHLBI NIH HHS R01 HL075826NHLBI NIH HHS R01 HL083077
6 · The paper itself

Abstract

Transcription factors are key regulators of the pattern of gene expression in a cell and directly control central processes such as proliferation, survival, self-renewal, and invasion. Given this critical role, the function of transcription factors is normally regulated closely, often through transient phosphorylation. Although transcription factors are not often directly modified by mutations in cancer cells, they frequently become activated constitutively through mutations affecting "upstream" pathways. By continually driving the expression of key target genes, these oncogenic transcription factors play a central role in tumor pathogenesis. One such transcription factor is the cAMP-regulatory element-binding protein (CREB), which can be activated through phosphorylation by a number of kinases, including Akt, p90Rsk, protein kinase A, and calcium/calmodulin-dependent kinases and regulates genes whose deregulated expression promotes oncogenesis, including cyclins, Bcl-2 family members, and Egr-1. CREB is overexpressed and constitutively phosphorylated in a number of forms of human cancer, including acute myeloid leukemia (AML) and non-small cell lung cancer, and appears to play a direct role in disease pathogenesis and prognosis. Although transcription factors have not been a central focus of drug development, recent advances suggest that CREB and other such proteins may be worthwhile targets for cancer therapy.

Indexed as

Cell ProliferationCyclic AMP Response Element-Binding ProteinCytokinesGene Expression Regulation, NeoplasticGranulocyte-Macrophage Colony-Stimulating FactorHumansLeukemia, Myeloid, AcuteLung NeoplasmsMyelopoiesisPhosphorylationProtein KinasesSignal TransductionCREB1 protein, humanCyclic AMP Response Element-Binding ProteinCytokinesGranulocyte-Macrophage Colony-Stimulating FactorProtein Kinases

Identifiers

PMID19351775
PMCPMC2883446
OpenAlexW2153747194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.