ArticleGenome biology2009
Identification and functional characterization of cis-regulatory elements in the apicomplexan parasite Toxoplasma gondii.
Article in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- TgAP2X-7 is a novel cell cycle-regulated transcription factor that plays an essential role inmSphere · 2025Article
- Massive invasion of organellar DNA drives nuclear genome evolution inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Transcriptome profile of halofuginone resistant and sensitive strains ofFrontiers in microbiology · 2023Article
- TgTKL1 Is a Unique Plant-Like Nuclear Kinase That Plays an Essential Role in Acute Toxoplasmosis.mBio · 2018Article
- Cis regulatory motifs and antisense transcriptional control in the apicomplexan Theileria parva.BMC genomics · 2016Article
- The Babesia bovis gene and promoter model: an update from full-length EST analysis.BMC genomics · 2014Article
- Bioinformatic prediction of gene functions regulated by quorum sensing in the bioleaching bacterium Acidithiobacillus ferrooxidans.International journal of molecular sciences · 2013Article
- Genome-wide upstream motif analysis of Cryptosporidium parvum genes clustered by expression profile.BMC genomics · 2013Article
- Involvement of a Toxoplasma gondii chromatin remodeling complex ortholog in developmental regulation.PloS one · 2011Article
- Cell cycle-dependent, intercellular transmission of Toxoplasma gondii is accompanied by marked changes in parasite gene expression.Molecular microbiology · 2011Article
- T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest.PloS one · 2010Article
- Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite.PLoS pathogens · 2010Article
- A decade of epigenetic research in Toxoplasma gondii.Molecular and biochemical parasitology · 2010Review
- Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii.PloS one · 2010Article
- High-resolution characterization of Toxoplasma gondii transcriptome with a massive parallel sequencing method.DNA research : an international journal for rapid publication of reports on genes and genomes · 2010Article
- Advances in parasite genomics: from sequences to regulatory networks.PLoS pathogens · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundToxoplasma gondii is a member of the phylum Apicomplexa, which consists entirely of parasitic organisms that cause several diseases of veterinary and human importance. Fundamental mechanisms of gene regulation in this group of protistan parasites remain largely uncharacterized. Owing to their medical and veterinary importance, genome sequences are available for several apicomplexan parasites. Their genome sequences reveal an apparent paucity of known transcription factors and the absence of canonical cis-regulatory elements. We have approached the question of gene regulation from a sequence perspective by mining the genomic sequence data to identify putative cis-regulatory elements using a de novo approach.
resultsWe have identified putative cis-regulatory elements present upstream of functionally related groups of genes and subsequently characterized the function of some of these conserved elements using reporter assays in the parasite. We show a sequence-specific role in gene-expression for seven out of eight identified elements.
conclusionsThis work demonstrates the power of pure sequence analysis in the absence of expression data or a priori knowledge of regulatory elements in eukaryotic organisms with compact genomes.
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