ArticleThe Journal of infectious diseases2009
Outbreak of severe respiratory disease associated with emergent human adenovirus serotype 14 at a US air force training facility in 2007.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed.
- Resurgence of Human Adenovirus Infections in the Korean Military Following the COVID-19 Pandemic.Journal of Korean medical science · 2026Article
- Adenoviral Pneumonia Outbreak in Immunocompetent Adults-A Missed Antimicrobial Stewardship Opportunity?Antibiotics (Basel, Switzerland) · 2025Article
- Risk Factors Associated With COVID-19 Transmission Among US Air Force Trainees in a Congregant Setting.JAMA network open · 2021Article
- Clinical and Immunological Characteristics of Patients With Adenovirus Infection at Different Altitude Areas in Tibet, China.Frontiers in cellular and infection microbiology · 2021Article
- Article
- Epidemiology of Human Adenoviruses: A 20-Year Retrospective Observational Study in Hospitalized Patients in Bern, Switzerland.Clinical epidemiology · 2020Article
- The molecular epidemiology of respiratory viruses in military trainees in Iran.Medical journal of the Islamic Republic of Iran · 2019Article
- Case report: a fatal case of disseminated adenovirus infection in a non-transplant adult haematology patient.BMC infectious diseases · 2018Article
- Severe Respiratory Viral Infections: New Evidence and Changing Paradigms.Infectious disease clinics of North America · 2017Review
- First Detection of Rotavirus Group C in Asymptomatic Pigs of Smallholder Farms in East Africa.Pathogens (Basel, Switzerland) · 2017Article
- Detection and Genetic Characterization of Adenovirus Type 14 Strain in Students with Influenza-Like Illness, New York, USA, 2014-2015.Emerging infectious diseases · 2017Article
- Viral Pneumonia and Acute Respiratory Distress Syndrome.Clinics in chest medicine · 2017Review
- Characteristics of Adenovirus Pneumonia in Korean Military Personnel, 2012-2016.Journal of Korean medical science · 2017Article
- Clinical Features and Courses of Adenovirus Pneumonia in Healthy Young Adults during an Outbreak among Korean Military Personnel.PloS one · 2017Article
- An easy method for preparation of Cre-loxP regulated fluorescent adenoviral expression vectors and its application for direct reprogramming into hepatocytes.Biotechnology reports (Amsterdam, Netherlands) · 2016Article
- A Decrease in Temperature and Humidity Precedes Human Rhinovirus Infections in a Cold Climate.Viruses · 2016Article
- Genotyping of human adenoviruses circulating in Southwest India.Virusdisease · 2016Article
- Type-specific clinical characteristics of adenovirus-associated influenza-like illness at five US military medical centers, 2009-2014.Influenza and other respiratory viruses · 2016Observational
- Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention.Seminars in respiratory and critical care medicine · 2016Review
- Low-Level Expression of the E1B 20-Kilodalton Protein by Adenovirus 14p1 Enhances Viral Immunopathogenesis.Journal of virology · 2016Article
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn 2007, a US Air Force training facility reported a cluster of severe respiratory illnesses associated with a rare human adenovirus (Ad) serotype, Ad14. We investigated this outbreak to better understand its epidemiology, clinical spectrum, and associated risk factors.
methodsData were collected from ongoing febrile respiratory illness (FRI) surveillance and from a retrospective cohort investigation. Because an Ad7 vaccine is in development, Ad7 antibody titers in pretraining serum samples from trainees with mild and those with severe Ad14 illness were compared.
resultsDuring 2007, an estimated 551 (48%) of 1147 trainees with FRI were infected with Ad14; 23 were hospitalized with pneumonia, 4 required admission to an intensive care unit, and 1 died. Among cohort members (n = 173), the Ad14 infection rate was high (50%). Of those infected, 40% experienced FRI. No cohort members were hospitalized. Male sex (risk ratio [RR], 4.7 [95% confidence interval {CI}, 2.2-10.1]) and an ill close contact (RR, 1.6 [95% CI, 1.2-2.2]) were associated with infection. Preexisting Ad7 neutralizing antibodies were found in 7 (37%) of 19 Ad14-positive trainees with mild illness but in 0 of 16 trainees with Ad14 pneumonia (P = .007).
conclusionsEmergence of Ad14, a rare Ad serotype, caused a protracted outbreak of respiratory illness among military recruits. Most infected recruits experienced FRI or milder illnesses. Some required hospitalization, and 1 died. Natural Ad7 infection may protect against severe Ad14 illness.
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