ArticleThe Journal of infectious diseases2009
A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14.
Article in The Journal of infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High pathogenicity of human adenovirus type 55 in adult males: a meta-analysis and phylogenetic study of HAdV-55 epidemics worldwide over the past six decades.Emerging microbes & infections · 2026Pooled it
- One virus-many strategies: type-specific interactions between human adenoviruses and innate immunity.Journal of virology · 2026Review
- Genomic Insights into the 2024 HAdV-14p1 Strain in China: Traced to Early Prevalent Strains.China CDC weekly · 2026Article
- Recombinant adenoviruses application for cancer vaccines: from genetic design to clinical translation.Frontiers in oncology · 2026Review
- Article
- Adenoviral fiber-knob based vaccination elicits efficient neutralizing antibodies and T cell responses against adenovirus infection.Virology journal · 2024Article
- The human adenovirus PI3K-Akt activator E4orf1 is targeted by the tumor suppressor p53.Journal of virology · 2024Article
- Detection of human adenoviruses in influenza-negative patients with respiratory tract infections in Nanning, China.Virology journal · 2023Article
- Characteristics and outcomes of acute hepatitis of unknown etiology in Egypt: first report of adult adenovirus-associated hepatitis.Infection · 2023Article
- Article
- Molecular epidemiology and phylogenetic analyses of human adenovirus in pediatric patients with acute respiratory infections from Hangzhou during COVID-19 pandemic.Frontiers in pediatrics · 2023Article
- Development of a Rapid Immuno-Based Screening Assay for the Detection of Adenovirus in Eye Infections.ACS omega · 2022Article
- Inactivation mechanisms of human adenovirus by e-beam irradiation in water environments.Applied microbiology and biotechnology · 2022Article
- Article
- Human adenovirus infections in pediatric population - An update on clinico-pathologic correlation.Biomedical journal · 2022Review
- Development and Application of a Fast Method to Acquire the Accurate Whole-Genome Sequences of Human Adenoviruses.Frontiers in microbiology · 2021Article
- Article
- First Identification of Human Adenovirus Subtype 21a in China With MinION and Illumina Sequencers.Frontiers in genetics · 2020Article
- Epidemiology of Human Adenoviruses: A 20-Year Retrospective Observational Study in Hospitalized Patients in Bern, Switzerland.Clinical epidemiology · 2020Article
- Reassessment of high prevalence human adenovirus detections among residents of two refugee centers in Kenya under surveillance for acute respiratory infections.Journal of medical virology · 2019Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman adenoviruses (Ads) typically cause mild illnesses in otherwise healthy hosts. We investigated a community-based outbreak that had substantial morbidity caused primarily by Ad14, an uncommon serotype.
methodsWe retrospectively reviewed the medical records of all patients with confirmed cases of Ad infection from 1 November 2006 through 31 July 2007 in Oregon. Isolates were typed by sequencing. We analyzed clinical and laboratory variables to identify risk factors for severe Ad14 disease.
resultsAd14 first emerged in Oregon in 2005. Of 67 cases of Ad infection detected during the study period, 40 (60%) involved Ad14. Most of the 38 Ad14-infected patients who had medical records available for review presented with fever and cough; 29 (76%) required hospitalization, 23 (61%) required supplemental oxygen, 18 (47%) required critical care, 9 (24%) required vasopressors, and 7 (18%) died. Lobar infiltrates on chest radiographs suggestive of bacterial pneumonia were common among those needing hospitalization. Older age, chronic underlying condition, low absolute lymphocyte counts, and elevated creatinine levels were associated with severe illness. Except for 1 case of possible hospital transmission, we identified no epidemiological links among patients.
conclusionAd14 emerged in Oregon in 2005 and became the predominant circulating type by 2007. Infection with this uncommon virus was primarily associated with a community-acquired pneumonia syndrome and caused substantial morbidity and mortality.
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