ArticleMolecular diagnosis & therapy2009
Study of NAT2 gene polymorphisms in an Indian population: association with plasma isoniazid concentration in a cohort of tuberculosis patients.
Article in Molecular diagnosis & therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania.PloS one · 2015Trial
- Pharmacogenomic heterogeneity ofAnnals of medicine · 2025Observational
- Metabolomics and lipidomics of plasma biomarkers for tuberculosis diagnostics using UHPLC-HRMS.Frontiers in cellular and infection microbiology · 2025Article
- The 3 HP regimen for tuberculosis preventive treatment: safety, dosage and related concerns during its large-scale implementation in countries like India.The Lancet regional health. Southeast Asia · 2024Review
- The Influence of NAT2 Genotypes on Isoniazid Plasma Concentration of Pulmonary Tuberculosis Patients in Southern Thailand.Tuberculosis and respiratory diseases · 2020Article
- Article
- ArylamineActa pharmaceutica Sinica. B · 2017Article
- N-acetyltransferase gene polymorphisms & plasma isoniazid concentrations in patients with tuberculosis.The Indian journal of medical research · 2017Article
- N-acetyltransferase 2 (NAT2) gene polymorphism as a predisposing factor for phenytoin intoxication in tuberculous meningitis or tuberculoma patients having seizures - A pilot study.The Indian journal of medical research · 2016Article
- NAT2 gene polymorphism: covert drug interaction causing phenytoin toxicity.The Indian journal of medical research · 2016Article
- Observational
- Prevention of isoniazid toxicity by NAT2 genotyping in Senegalese tuberculosis patients.Toxicology reports · 2016Article
- Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate.Pharmacology research & perspectives · 2015Article
- Cutaneous adverse drug reactions in Indian population: A systematic review.Indian dermatology online journal · 2014Article
- Comparison between acetylator phenotype and genotype polymorphism of n-acetyltransferase-2 in tuberculosis patients.Hepatology international · 2012Article
- NAT2, CYP2C9, CYP2C19, and CYP2E1 genetic polymorphisms in anti-TB drug-induced maculopapular eruption.European journal of clinical pharmacology · 2011Article
- Is there any difference between acetylator phenotypes in tuberculosis patients and healthy subjects?European journal of clinical pharmacology · 2010Article
- Determination of Arylamine N-Acetyltransferase 2 Acetylation Genotype by PCR and Phenotyping Using Dapsone Through High-Pressure Liquid Chromatography Assay: A Gender Wise Study.Dose-response : a publication of International Hormesis SocietyArticle
- Clinical and Molecular Risk Factors of Anti-tubercular Therapy Induced Hepatitis.Journal of clinical and experimental hepatologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPolymorphisms of the N-acetyltransferase 2 gene (NAT2) vary remarkably between populations of different ethnic origin. The NAT2 gene determines the individual's acetylator status to metabolize drugs and xenobiotics, influencing their toxicity and efficacy profiles. This study investigates the frequencies of the most commonly studied NAT2 polymorphisms in a southwestern Indian population and compares these with those reported in other Indian and world populations. The association of these polymorphisms with plasma isoniazid concentrations in a cohort of tuberculosis patients has also been investigated.
methodsNAT2 genotyping of 201 subjects was carried out by PCR-restriction fragment length polymorphism (PCR-RFLP) analysis and DNA sequencing. Acetylation phenotypes were predicted from NAT2 genotypes. The association of NAT2 genotypes with plasma isoniazid concentrations was determined by measuring the plasma levels in tuberculosis patients at different time points using reverse-phase high-performance liquid chromatography (HPLC).
resultsThe predominant alleles found in this study population were NAT2*5B and NAT2*6A, while NAT2*5B/*6A and NAT2*6A/*6A were the most frequent genotypes; the frequency varied widely from other reported studies in the Indian population. The distribution of slow, intermediate, and fast acetylators was 55%, 32%, and 13%, respectively. We observed relatively higher plasma concentrations of isoniazid in our patients than those reported in other similar studies, and they correlated well with the NAT2 genotypes.
conclusionThe results suggested high variation in the frequencies of NAT2 alleles and genotypes within Indian populations, which influence plasma isoniazid concentrations. Further studies of the relationship between NAT2 genotypes and adverse drug events are required to make genotyping a helpful tool for optimizing the isoniazid therapeutic response and minimizing adverse drug reactions, particularly in countries with a high burden of tuberculosis.
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