ArticleThe Journal of comparative neurology2009
Regulation of neonatal development of retinal ganglion cell dendrites by neurotrophin-3 overexpression.
Article in The Journal of comparative neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Cholinergic Waves Have a Modest Influence on the Transcriptome of Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- In vivo imaging of the inner retinal layer structure in mice after eye-opening using visible-light optical coherence tomography.Experimental eye research · 2021Article
- Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification.Neural development · 2021Article
- Results from the Population-Based Gutenberg Health Study Revealing Four Altered Autoantibodies in Retinal Vein Occlusion Patients.Journal of ophthalmology · 2020Article
- Brn3a and Brn3b knockout mice display unvaried retinal fine structure despite major morphological and numerical alterations of ganglion cells.The Journal of comparative neurology · 2019Article
- Postnatal developmental dynamics of cell type specification genes in Brn3a/Pou4f1 Retinal Ganglion Cells.Neural development · 2018Article
- Characterization of retinal ganglion cell, horizontal cell, and amacrine cell types expressing the neurotrophic receptor tyrosine kinase Ret.The Journal of comparative neurology · 2018Article
- Treadmill exercise with bone marrow stromal cells transplantation potentiates recovery of locomotor function after spinal cord injury in rats.Journal of exercise rehabilitation · 2017Article
- Treadmill exercise facilitates recovery of locomotor function through axonal regeneration following spinal cord injury in rats.Journal of exercise rehabilitation · 2016Article
- Long-Term Protection of Retinal Ganglion Cells and Visual Function by Brain-Derived Neurotrophic Factor in Mice With Ocular Hypertension.Investigative ophthalmology & visual science · 2016Article
- Retinal Ganglion Cell Loss is Delayed Following Optic Nerve Crush in NLRP3 Knockout Mice.Scientific reports · 2016Article
- Subtype-dependent Morphological and Functional Degeneration of Retinal Ganglion Cells in Mouse Models of Experimental Glaucoma.Journal of nature and science · 2015Article
- Experience-dependent and independent binocular correspondence of receptive field subregions in mouse visual cortex.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina.The Journal of comparative neurology · 2014Article
- A laser-induced mouse model of chronic ocular hypertension to characterize visual defects.Journal of visualized experiments : JoVE · 2013Article
- Multimodal photoacoustic ophthalmoscopy in mouse.Journal of biophotonics · 2013Article
- Construction of a eukaryotic expression plasmid for human retina-derived neurotrophin-3.Neural regeneration research · 2013Article
- Sustained ocular hypertension induces dendritic degeneration of mouse retinal ganglion cells that depends on cell type and location.Investigative ophthalmology & visual science · 2013Article
- TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Undersized dendritic arborizations in retinal ganglion cells of the rd1 mutant mouse: a paradigm of early onset photoreceptor degeneration.The Journal of comparative neurology · 2012Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The morphology of dendrites constrains and reflects the nature of synaptic inputs to neurons. The visual system has served as a useful model to show how visual function is determined by the arborization patterns of neuronal processes. In retina, light ON and light OFF responding ganglion cells selectively elaborate their dendritic arbors in distinct sublamina, where they receive, respectively, inputs from ON and OFF bipolar cells. During neonatal maturation, the bilaminarly distributed dendritic arbors of ON-OFF retinal ganglion cells (RGCs) are refined to more narrowly localized monolaminar structures characteristic of ON or OFF RGCs. Recently, brain-derived neurotrophic factor (BDNF) has been shown to regulate this laminar refinement, and to enhance the development of dendritic branches selectively of ON RGCs. Although other related neurotrophins are known to regulate neuronal process formation in the central nervous system, little is known about their action in maturing retina. Here, we report that overexpression of neurotrophin-3 (NT-3) in the eye accelerates RGC laminar refinement before eye opening. Furthermore, NT-3 overexpression increases dendritic branch number but reduces dendritic elongation preferentially in ON-OFF RGCs, a process that also occurs before eye opening. NT-3 overexpression does affect dendritic maturation in ON RGCs, but to a much less degree. Taken together, our results suggest that NT-3 and BDNF exhibit overlapping effects in laminar refinement but distinct RGC-cell-type specific effects in shaping dendritic arborization during postnatal development.
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