ArticleInternational journal of cancer2009
Effects of dietary factors and the NAT2 acetylator status on gastric cancer in Koreans.
Article in International journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 7 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 7 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Dietary intake and cancer incidence in Korean adults: a systematic review and meta-analysis of observational studies.Epidemiology and health · 2023Pooled it
- Association between chili pepper consumption and risk of gastrointestinal-tract cancers: A meta-analysis.Frontiers in nutrition · 2022Pooled it
- Soy and isoflavone consumption and risk of gastrointestinal cancer: a systematic review and meta-analysis.European journal of nutrition · 2016Pooled it
- The impact of capsaicin intake on risk of developing gastric cancers: a meta-analysis.Journal of gastrointestinal cancer · 2014Pooled it
- Gene-diet interactions in gastric cancer risk: a systematic review.World journal of gastroenterology · 2014Pooled it
- N-acetyltransferase 2 status and gastric cancer risk: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Fermented and non-fermented soy food consumption and gastric cancer in Japanese and Korean populations: a meta-analysis of observational studies.Cancer science · 2011Pooled it
- Association of Soy Foods With Gastric Cancer ConsideringJournal of gastric cancer · 2024Article
- The role of iron homeostasis and iron-mediated ROS in cancer.American journal of cancer research · 2021Review
- High Spicy Food Intake and Risk of Cancer: A Meta-analysis of Case-control Studies.Chinese medical journal · 2017Article
- Catalytic properties and heat stabilities of novel recombinant human N-acetyltransferase 2 allozymes support existence of genetic heterogeneity within the slow acetylator phenotype.Archives of toxicology · 2017Article
- Intake of specific nonfermented soy foods may be inversely associated with risk of distal gastric cancer in a Chinese population.The Journal of nutrition · 2013Article
- ITGA1 polymorphisms and haplotypes are associated with gastric cancer risk in a Korean population.World journal of gastroenterology · 2013Article
- Association of NAT2 phenotype with risk of head and neck carcinoma: A meta-analysis.Oncology letters · 2012Article
- Anti-tumour effects of small interfering RNA targeting anion exchanger 1 in experimental gastric cancer.British journal of pharmacology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Environmental dietary carcinogens and genetic polymorphisms in metabolic enzymes have been reported to be the risk factors for gastric cancer. This study was undertaken to investigate the effects of the diet, the N-acetyltransferase (NAT) 2 acetylation status and their interaction on gastric cancer risk. The study population consisted of 471 gastric cancer patients and 471 age- and sex-matched control subjects. NAT2 genotypes were identified using single-nucleotide primer extension reaction methods. Thirty-one alleles related to 12 polymorphism sites were assayed in this study. Significantly increased odds ratios were observed in former smokers (OR = 2.39, 95% CI = 1.57-3.62), heavy drinkers (OR = 1.28, 95% CI = 1.06-1.55) and individuals who eat well-done meat (OR = 1.24, 95% CI = 1.09-1.41). The odds ratios (95% CI) for high intake of kimchi, stews and soybean paste were 3.27 (2.44-4.37), 1.96 (1.50-2.58) and 1.63 (1.24-2.14), respectively. The NAT2 genotype alone was not associated with gastric cancer risk. A significant gene-environment interaction was observed between environmental carcinogens and NAT2 genotypes. The odds ratios for kimchi, stews and soybean paste were higher in slow/intermediate acetylators than in rapid acetylators. The odds ratios for slow/intermediate acetylators were 2.28 (95% CI: 1.29-4.04) for light smokers and 3.42 (95% CI: 2.06-5.68) for well-done meat intake. The NAT2 acetylator genotype may be an important modifier of the effects of environmental factors on gastric cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.