Trial reportInternational journal of cancer2009
Family history of cancer and nonmalignant lung diseases as risk factors for lung cancer.
Trial report in International journal of cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies.Molecular genetics and genomics : MGG · 2014Pooled it
- Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- [Systematic review of the relationship between family history of lung cancer and lung cancer risk].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2010Pooled it
- Integrated molecular dynamics elucidation of TP53 H179 zinc-binding variants: genomic and structural characterization across NSCLC subtypes.Frontiers in bioinformatics · 2026Article
- Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium.International journal of cancer · 2025Article
- Rate of Pathogenic Germline Variants in Patients With Lung Cancer.JCO precision oncology · 2023Review
- The Potential Role of MUC16 (CA125) Biomarker in Lung Cancer: A Magic Biomarker but with Adversity.Diagnostics (Basel, Switzerland) · 2022Review
- Lung cancer risk in non-smoking females with a familial history of cancer: a multi-center prospective cohort study in China.Journal of the National Cancer Center · 2021Article
- Characteristics of Ground-Glass Nodules Detected by Low-Dose Computed Tomography as a Regular Health Examination Among Chinese Hospital Employees and Their Parents.Frontiers in oncology · 2021Article
- Inherited Rare, Deleterious Variants in ATM Increase Lung Adenocarcinoma Risk.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2020Article
- Survival associated with chronic obstructive pulmonary disease among SEER-Medicare beneficiaries with non-small-cell lung cancer.International journal of chronic obstructive pulmonary disease · 2019Article
- Factors Associated With Small Aggressive Non-Small Cell Lung Cancers in the National Lung Screening Trial: A Validation Study.JNCI cancer spectrum · 2018Article
- Understanding the role of family dynamics, perceived norms, and lung cancer worry in predicting second-hand smoke avoidance among high-risk lung cancer families.Journal of health psychology · 2017Article
- CRTC2 and PROM1 expression in non-small cell lung cancer: analysis by Western blot and immunohistochemistry.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Joint effects of environmental exposures and familial susceptibility to lung cancer in Chinese never smoking men and women.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2014Article
- Concurrent molecular alterations in tumors with germ line epidermal growth factor receptor T790M mutations.Clinical lung cancer · 2013Article
- Chapter 6: Lung cancer in never smokers: epidemiology and risk prediction models.Risk analysis : an official publication of the Society for Risk Analysis · 2012Article
- Integrative genomic analysis reveals extended germline homozygosity with lung cancer risk in the PLCO cohort.PloS one · 2012Article
- A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- The detection of chromosomal aneusomy by fluorescence in situ hybridization in sputum predicts lung cancer incidence.Cancer prevention research (Philadelphia, Pa.) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Family history (FH) of lung cancer is an established risk factor for lung cancer, but the modifying effect of smoking in relatives has been rarely examined. Also, the role of FH of nonmalignant lung diseases on lung cancer risk is not well known. We examined the role of FH of cancer and nonmalignant lung diseases in lung cancer risk overall, and by personal smoking, FH of smoking and histology in 1,946 cases and 2,116 population-based controls within the Environment And Genetics in Lung cancer Etiology (EAGLE) study. Odds ratios (ORs) and 95% CI from logistic regression were calculated adjusting for age, gender, residence, education and cigarette smoking. FH of lung cancer in any family member was associated with increased lung cancer risk (OR = 1.57, 95% CI = 1.25-1.98). The odds associated with fathers', mothers' and siblings' history of lung cancer were 1.41, 2.14 and 1.53, respectively. The associations were generally stronger in never smokers, younger subjects and for the adenocarcinoma and squamous cell carcinoma subtypes. FH of chronic bronchitis and pneumonia was associated with increased (OR = 1.49, 95% CI = 1.23-1.80) and decreased (OR = 0.73, 95% CI = 0.61-0.87) lung cancer risk, respectively. FH of lung cancer and nonmalignant lung diseases affected lung cancer risk independently, and did not appear to be modified by FH of smoking.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.