ArticleJournal of cellular biochemistry2009
HACE1: A novel repressor of RAR transcriptional activity.
Article in Journal of cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch.Disease models & mechanisms · 2019Article
- Genetic susceptibility to neuroblastoma: current knowledge and future directions.Cell and tissue research · 2018Review
- Common variations withinOncoTargets and therapy · 2017Article
- HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex.Viruses · 2016Article
- HACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome.Journal of medical genetics · 2015Article
- Ubiquitylation of nuclear receptors: new linkages and therapeutic implications.Journal of molecular endocrinology · 2015Review
- Role of Acinus in regulating retinoic acid-responsive gene pre-mRNA splicing.Journal of cellular physiology · 2015Article
- The SAP motif and C-terminal RS- and RD/E-rich region influences the sub-nuclear localization of Acinus isoforms.Journal of cellular biochemistry · 2014Article
- HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.Nature communications · 2014Article
- Vitamin A and retinoid signaling: genomic and nongenomic effects.Journal of lipid research · 2013Review
- Role of COUP-TFI during retinoic acid-induced differentiation of P19 cells to endodermal cells.Journal of cellular physiology · 2013Article
- HACE1 is a tumor suppressor gene candidate in natural killer cell neoplasms.The American journal of pathology · 2013Article
- HACE1 (HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1).Atlas of genetics and cytogenetics in oncology and haematology · 2012Article
- Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.Nature genetics · 2012Article
- Role of SF-1 and DAX-1 during differentiation of P19 cells by retinoic acid.Journal of cellular physiology · 2012Article
- Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targets.Journal of biomedicine & biotechnology · 2011Review
- The ETS family member TEL binds to nuclear receptors RAR and RXR and represses gene activation.PloS one · 2011Article
- The Ski protein negatively regulates Siah2-mediated HDAC3 degradation.Biochemical and biophysical research communications · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The diverse biological actions of retinoic acid (RA) are mediated by RA receptors (RARs) and retinoid X receptors (RXRs). While the coregulatory proteins that interact with the ligand-dependent AF-2 in the E region are well studied, the ligand-independent N-terminal AF-1 domain-interacting partners and their influence(s) on the function of RARs are poorly understood. HECT domain and Ankyrin repeat containing E3 ubiquitin-protein ligase (HACE1) was isolated as a RARbeta(3) AB region interacting protein. HACE1 interacts with RARbeta(3) both in in vitro GST pull-down and in cell-based coprecipitation assays. The interaction sites map to the N terminus of RARbeta(3) and the C terminus of HACE1. HACE1 functionally represses the transcriptional activity of RARalpha(1), RARbeta isoforms 1, 2, and 3, but not RARgamma(1) in luciferase reporter assays. In addition, HACE1 represses the endogenous RAR-regulated genes CRABP II, RIG1 and RARbeta(2), but not RAI3 in CAOV3 cells. Mutation of the putative catalytic cysteine (C876 of LF HACE1), which is indispensable for its E3 ubiquitin ligase activity, does not alter the repressive effect of HACE1 on the transcriptional activity of RARbeta(3). On the other hand, HACE1 inhibits the RA dependent degradation of RARbeta(3). It is possible that the repression of RAR-regulated transcription by HACE1 is due to its ability to inhibit the RA-dependent degradation of RARs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.