ArticleHuman brain mapping2009
Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals.
Article in Human brain mapping, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 57 citations in OpenAlex.
- Mapping the task-general and task-specific neural correlates of speech production: Meta-analysis and fMRI direct comparisons of category fluency and picture naming.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cognitive Impairments Related to COMT and Neuregulin 1 Phenotypes as Transdiagnostic Markers in Schizophrenia Spectrum Patients.Journal of clinical medicine · 2024Article
- Toward the Language Oscillogenome.Frontiers in psychology · 2018Article
- A genome-wide supported psychiatric risk variant in NCAN influences brain function and cognitive performance in healthy subjects.Human brain mapping · 2015Article
- Increased neural activity during overt and continuous semantic verbal fluency in major depression: mainly a failure to deactivate.European archives of psychiatry and clinical neuroscience · 2014Article
- Zinc finger protein 804A (ZNF804A) and verbal deficits in individuals with autism.Journal of psychiatry & neuroscience : JPN · 2014Article
- Review
- A genome-wide supported variant in CACNA1C influences hippocampal activation during episodic memory encoding and retrieval.European archives of psychiatry and clinical neuroscience · 2014Article
- A Neuregulin-1 schizophrenia susceptibility variant causes perihippocampal fiber tract anomalies in healthy young subjects.Brain and behavior · 2014Article
- Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample.Schizophrenia research · 2013Article
- The effect of neurogranin on neural correlates of episodic memory encoding and retrieval.Schizophrenia bulletin · 2013Article
- Dedifferentiation and substitute strategy: deconstructing the processing-speed impairment in schizophrenia.Schizophrenia research · 2012Article
- Genetic associations between neuregulin-1 SNPs and neurocognitive function in multigenerational, multiplex schizophrenia families.Psychiatric genetics · 2012Article
- Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2011Review
- Intermediate phenotypes in psychiatric disorders.Current opinion in genetics & development · 2011Review
- The effects of a DTNBP1 gene variant on attention networks: an fMRI study.Behavioral and brain functions : BBF · 2010Article
- Article
- Executive function, neural circuitry, and genetic mechanisms in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Review
- Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia.Schizophrenia research · 2009Article
- Schizophrenia pathophysiology: are we any closer to a complete model?Annals of general psychiatry · 2009Article
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Authors and funding
13 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired performance in verbal fluency tasks is an often replicated finding in schizophrenia. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal and temporal areas. Since schizophrenia has a high heritability, it is of interest whether susceptibility genes for the disorder, such as NRG1, modulate verbal fluency performance and its neural correlates. Four hundred twenty-nine healthy individuals performed a semantic and a lexical verbal fluency task. A subsample of 85 subjects performed an overt semantic verbal fluency task while brain activation was measured with functional magnetic resonance imaging (MRI). NRG1 (SNP8NRG221533; rs35753505) status was determined and correlated with verbal fluency performance and brain activation. For the behavioral measure, there was a linear effect of NRG1 status on semantic but not on lexical verbal fluency. Performance decreased with number of risk-alleles. In the fMRI experiment, decreased activation in the left inferior frontal and the right middle temporal gyri as well as the anterior cingulate gyrus was correlated with the number of risk-alleles in the semantic verbal fluency task. NRG1 genotype does influence language production on a semantic level in conjunction with the underlying neural systems. These findings are in line with results of studies in schizophrenia and may explain some of the cognitive and brain activation variation found in the disorder. More generally, NRG1 might be one of several genes that influence semantic language capacities.
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