ArticleXenobiotica; the fate of foreign compounds in biological systems2009
Sulfation of dietary flavonoids by human sulfotransferases.
Article in Xenobiotica; the fate of foreign compounds in biological systems, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
- Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation.Science advances · 2023Article
- In Vitro Liver Metabolism of Six Flavonoid C-Glycosides.Molecules (Basel, Switzerland) · 2021Article
- Computational Analysis of Chemical Space of Natural Compounds Interacting with Sulfotransferases.Molecules (Basel, Switzerland) · 2021Article
- In Vitro Metabolism of Six C-Glycosidic Flavonoids fromInternational journal of molecular sciences · 2021Article
- Biopharmaceutical Evaluation of Capsules with Lyophilized Apple Powder.Molecules (Basel, Switzerland) · 2021Article
- The Role of Sulfotransferases in Liver Diseases.Drug metabolism and disposition: the biological fate of chemicals · 2020Review
- Sulfation of hesperetin, naringenin and apigenin by the human cytosolic sulfotransferases: a comprehensive analysis.Natural product research · 2020Article
- Sulfate conjugation of daphnetin by the human cytosolic sulfotransferases.Journal of ethnopharmacology · 2016Article
- Identification and characterization of sulfonyltransferases catalyzing ethyl sulfate formation and their inhibition by polyphenols.International journal of legal medicine · 2016Article
- Intratumoral estrogen sulfotransferase induction contributes to the anti-breast cancer effects of the dithiocarbamate derivative TM208.Acta pharmacologica Sinica · 2015Article
- Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells.Acta pharmacologica Sinica · 2014Article
- Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways.RSC advances · 2012Article
- SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies.Molecular pharmaceutics · 2012Article
- Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis.Current drug metabolism · 2011Review
- Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison.The Journal of pharmacy and pharmacology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Dietary flavonoids catechin, epicatechin, eriodictyol, and hesperetin were investigated as substrates and inhibitors of human sulfotransferases (hSULTs). Purified recombinant proteins and human intestine cytosol were used as enzyme sources. hSULT1A1 and hSULT1A3 as well as human intestine cytosol can catalyse the sulfation of the investigated flavonoids. Sulfation of catechin, epicatechin, eriodictyol, and hesperetin by recombinant hSULTs showed substrate inhibition at high flavonoid concentrations. Hesperetin and eriodictyol are potent inhibitors of purified hSULT1A1, hSULT1A3, hSULT1E1, and hSULT2A1. Catechin and epicatechin inhibited hSULT1A1 and hSULT1A3, but not hSULT1E1 and hSULT2A1. The sulfation efficacy and potency of inhibition is related to the C-ring structure of flavonoids. These results suggest that dietary flavonoids may regulate human SULT activity and, therefore, affect the regulation of hormones and neurotransmitters, detoxification of drugs, and the bioactivation of pro- carcinogens and pro-mutagens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.