Evidence map›Paper›PMID 19350378›Full record

Trial reportAIDS and behavior2010

Stress biomarkers as outcomes for HIV+ prevention: participation, feasibility and findings among HIV+ Latina and African American mothers.

Dorie A Glover, Elena F Garcia-Aracena, Patricia Lester, Eric Rice, Mary Jane Rothram-Borus

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Dorie A GloverSemel Institute, Child Division, Department of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Blvd., Los Angeles, CA 90024, USA. dglover@mednet.ucla.edu
Elena F Garcia-Aracena
Patricia Lester
Eric Rice
Mary Jane Rothram-Borus
University of California, Los Angeles · USUniversity of California System · USNeurobehavioral Systems · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
MOTHERS LIVING WITH HIV AND THEIR ADOLESCENT CHILDRENR01MH068194 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTHERAM, MARY JANE · 2003 to 2007
$7.0M
Social Network-Based HIV Prevention for Homeless YouthK01MH080605 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICE, ERIC · 2007 to 2011
$724k
NCRR NIH HHS M01 RR000865NCRR NIH HHS M01-RR00865NIMH NIH HHS K01 MH080605NIMH NIH HHS L30 MH075197NIMH NIH HHS R01 MH-068194NIMH NIH HHS R01 MH068194
6 · The paper itself

Abstract

Mothers living with HIV (MLH) are at high risk for acute and chronic stress, given challenges related to their HIV status, ethnicity, economic and urban living conditions. Biomarkers combined into a composite index show promise in quantifying psychosocial stress in healthy people, but have not yet been examined among MLH. According, we examined potential biomarker correlates of stress [cortisol and catecholamines from home-collected urine and basic health indicators (blood pressure, height and weight, waist-to-hip ratio) measured during an interview] among 100 poor African American and Latina mothers MLH and demographic-matched control mothers without HIV (n = 50). Participants had been enrolled in a randomized controlled trial about 18 months earlier and had either received (MLH-I) or were awaiting (MLH-W) the psychosocial intervention. Participation was high, biomarkers were correctly collected for 93% of cases, and a complete composite biomarker index (CBI) calculated for 133 mothers (mean age = 42). As predicted, MLH had a significantly higher CBI than controls, but there was no CBI difference across ethnicity or intervention group. CBI predicted CD4 counts independently after controlling for age, years since diagnosis, prior CD4 counts, medication adherence, and depression symptoms. The study demonstrates acceptability, feasibility and potential utility of community-based biomarker collections in evaluating individual differences in psychosocial stress.

Indexed as

Stress, PsychologicalAdaptation, PsychologicalAdultBiomarkersBlack or African AmericanCatecholaminesFeasibility StudiesFemaleHispanic or LatinoHIV InfectionsHumansHydrocortisoneInterviews as TopicMental HealthMothersPatient Acceptance of Health CareBiomarkersCatecholaminesHydrocortisone

Identifiers

PMID19350378
PMCPMC2834765
OpenAlexW1985361255

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.