ArticleEuropean radiology2009
Penumbra Stroke System as an "add-on" for the treatment of large vessel occlusive disease following thrombolysis: first results.
Article in European radiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Guideline
- Flat detector CT in the evaluation of brain parenchyma, intracranial vasculature, and cerebral blood volume: a pilot study in patients with acute symptoms of cerebral ischemia.AJNR. American journal of neuroradiology · 2010Trial
- Endovascular mechanical recanalization of acute ischaemic stroke in octogenarians.European radiology · 2016Article
- Endovascular therapy for ischemic stroke.Journal of clinical neurology (Seoul, Korea) · 2015Review
- Neurothrombectomy in the treatment of acute ischaemic stroke.Nature reviews. Neurology · 2013Review
- A meta-analysis of observational intra-arterial stroke therapy studies using the Merci device, Penumbra system, and retrievable stents.AJNR. American journal of neuroradiology · 2013Article
- Acute stroke treatment using the Penumbra endovascular mechanical thrombolysis device: a single-centre experience.La Radiologia medica · 2012Article
- [Industry-funded therapy studies: what is in the pipeline?].Der Nervenarzt · 2012Article
- The usefulness of compliant balloon for recanalization of acute ischemic stroke.Journal of cerebrovascular and endovascular neurosurgery · 2012Article
- Feasibility of cerebral blood volume mapping by flat panel detector CT in the angiography suite: first experience in patients with acute middle cerebral artery occlusions.AJNR. American journal of neuroradiology · 2012Article
- Reperfusion by combined thrombolysis and mechanical thrombectomy in acute stroke: effect of collateralization, mismatch, and time to and grade of recanalization on clinical and tissue outcome.AJNR. American journal of neuroradiology · 2012Article
- The phenox clot retriever as part of a multimodal mechanical thrombectomy approach in acute ischemic stroke: single center experience in 56 patients.TheScientificWorldJournal · 2012Article
- Advances in stroke therapy.Drug delivery and translational research · 2011Article
- The Comparison of Outcome between Thromboaspiration and Aggressive Mechanical Clot Disruption in Treating Hyperacute Stroke Patients.Journal of Korean Neurosurgical Society · 2011Article
- Achieving faster recanalization times by IA thrombolysis in acute ischemic stroke: where should we direct our efforts?Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2011Article
- Initial experience with the Penumbra Stroke System for recanalization of large vessel occlusions in acute ischemic stroke.Neuroradiology · 2011Article
- Current recommendations for endovascular interventions in the treatment of ischemic stroke.Current atherosclerosis reports · 2010Article
- Acute stroke magnetic resonance imaging: current status and future perspective.Neuroradiology · 2010Review
- Predictors for good functional outcome after neurocritical care.Critical care (London, England) · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Penumbra Stroke System (PSS) was cleared for use in patients with ischemic stroke by the FDA in January 2008. We describe our experience of using this new system in acute large vessel occlusive disease following thrombolysis. Fifteen consecutive patients (mean age 60 years) suffering from acute ischemic stroke were treated with the PSS after intravenous or intra-arterial standard treatment with tissue plasminogen activator (n = 14) or ReoPro (n = 1). All patients presented with TIMI 3 before use of the PSS. Carotid stenting (n = 3) and intracranial balloon angioplasty or stenting (n = 2) were performed if indicated. Neurological evaluation was performed using the NIHSS score and the mRS score. Initial median NIHSS score in 12 patients with occlusions in the anterior circulation was 15; three patients with basilar artery occlusion presented with coma. Median symptom to procedure start time was 151 min. In the anterior circulation, 9 of the 12 target vessels were recanalised successfully (TIMI 2 and 3). The rate of patients with independent clinical outcome (mRS </= 2) was 42%. One patient died 5 days after unsuccessful treatment, one after 28 days and one after 85 days owing to heart attack. Basilar artery occlusions could be recanalised in all cases to TIMI 3. The clinical result after 90 days was mRS 4 in two cases and mRS 5 in one case. Symptomatic haemorrhage did not occur. The PSS can safely be used for recanalisation in patients with acute ischemic stroke due to large vessel occlusion, who have already received thrombolysis treatment. The recanalisation rate was 80%. Symptomatic haemorrhage did not occur. Randomized trials may demonstrate that endovascular mechanical thrombectomy improves patient outcome.
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