ReviewJournal of neural transmission (Vienna, Austria : 1996)2009
Historical evolution of the neurotransmission concept.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits.Bioscience reports · 2026Review
- A golden age of muscarinic acetylcholine receptor modulation in neurological diseases.Nature reviews. Drug discovery · 2024Review
- Review
- The Hebb Synapse Before Hebb: Theories of Synaptic Function in Learning and Memory Before , With a Discussion of the Long-Lost Synaptic Theory of William McDougall.Frontiers in behavioral neuroscience · 2021Review
- Why Study the History of Neuroscience?Frontiers in behavioral neuroscience · 2019Review
- Knowing a synapse when you see one.Frontiers in neuroanatomy · 2015Article
- The purinergic neurotransmitter revisited: a single substance or multiple players?Pharmacology & therapeutics · 2014Review
- Structure activity relationship of synaptic and junctional neurotransmission.Autonomic neuroscience : basic & clinical · 2013Review
- The maze of the cerebrospinal fluid discovery.Anatomy research international · 2013Review
- Neurotransmitters and integration in neuronal-astroglial networks.Neurochemical research · 2012Review
- Kölliker–Fuse neurons send collateral projections to multiple hypoxia-activated and nonactivated structures in rat brainstem and spinal cord.Brain structure & function · 2012Article
- Innervation of ventricular and periventricular brain compartments.Brain research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this review we analyse the evolution of the neurotransmission phenomenon, whose nature have had three basic historical interpretations; a first, of an humoral nature, formulated by the classical Greeks (Alexandrian School), and which lasted, thanks to the work of Galen, until the sixteenth century (the theory of spiritus animalis); a second, purely mechanical one, developed on the basis of Cartesian conceptions, and which dominated in the seventeenth and eighteenth centuries; and finally, the electrochemical interpretation, which emerged in the nineteenth century, coinciding with the coming of age of numerous scientific disciplines, such as microscopic anatomy (Cajal), physiology (Sherrington), pharmacology (Bernard, Schmiedeberg) or experimental chemistry (Hensing). This latest interpretation can be broken down into an electrical hypothesis, dominant in the nineteenth century (Galvani, Du Bois-Reymond), and the current chemical hypothesis, which can be dated back to 1904, thanks to the research and the research by Elliott (chemical mediators) and Langley (receptive substances) on sympathetic stimulation. Finally, we describe the process of the discovery of the different neurotransmitters and neuroreceptors, and analyse the new interpretations postulated in relation to the neurotransmission concept at the dawn of the twenty-first century.
Indexed as
Identifiers
19350218What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.