Evidence map›Paper›PMID 19350102›Full record

ReviewThrombosis and haemostasis2009

The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders.

Ellen C Keeley, Borna Mehrad, Robert M Strieter

Open access · greenAbstract readReview
In one paragraph

Review in Thrombosis and haemostasis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 53 citations in OpenAlex.

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  12. Circulating fibrocytes as predictors of adverse events in unstable angina.Translational research : the journal of laboratory and clinical medicine · 2016
    Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ellen C KeeleyDivisions of Cardiology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Borna Mehrad
Robert M Strieter
University of Virginia · US

Funding

NK cells in host defense against invasive aspergillosisR01HL073848 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA · 2003 to 2013
$3.3M
Fibrocytes in human pulmonary fibrosisR01HL098329 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA, ROSE, C EDWARD · 2011 to 2015
$2.7M
NHLBI NIH HHS R01 HL073848NHLBI NIH HHS R01 HL098329
6 · The paper itself

Abstract

Fibrocytes are bone marrow-derived mesenchymal progenitor cells that express markers of leukocytes, haematopoietic progenitor cells, and fibroblasts. They play a pivotal role in tissue remodelling and fibrosis in both physiologic and pathologic settings. Fibrocytes are unique in that they are capable of differentiating into fibroblasts and myofibroblasts, as well as adipocytes. In this review we will present data supporting the critical role they play in the pathogenesis of chronic inflammatory fibrotic diseases of the lungs, heart and vasculature.

Indexed as

AnimalsCardiovascular DiseasesCell DifferentiationCell MovementFibroblastsFibrosisHumansInflammationLung DiseasesMesenchymal Stem CellsSignal Transduction

Identifiers

PMID19350102
PMCPMC3353523
OpenAlexW2071060504

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.