ArticleNature cell biology2009
Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt.
Article in Nature cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- No evidence for aversive associative olfactory memory through metamorphosis in Drosophila.Biology open · 2026Article
- Leptin Acts as a Peripheral Tropic Signal to Tune Steroidogenesis.bioRxiv : the preprint server for biology · 2026Article
- Hsp40 co-chaperone Droj2 temporally regulates EcRA dynamics during collective cell migration.Frontiers in cell and developmental biology · 2026Article
- Ecdysone signaling-induced dumpless1 expression controls nurse cell dumping in Drosophila oogenesis.Nature communications · 2025Article
- Ecdysone regulates phagocytic cell fate of epithelial cells in developing Drosophila eggs.The Journal of cell biology · 2025Article
- A Head-Specific Transcriptomic Study Reveals Key Regulatory Pathways for Winter Diapause in the Mosquito Culex pipiens.Archives of insect biochemistry and physiology · 2025Article
- Abrupt-mediated control of ninjurins regulates Drosophila sessile haemocyte compartments.Development (Cambridge, England) · 2024Article
- Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2024Article
- Hox gene-specific cellular targeting using split intein Trojan exons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Finishing the egg.Genetics · 2024Article
- Transcriptome analysis reveals temporally regulated genetic networks during Drosophila border cell collective migration.BMC genomics · 2023Article
- Single-cell transcriptomics illuminates regulatory steps driving anterior-posterior patterning of Drosophila embryonic mesoderm.Cell reports · 2023Article
- Ecdysteroid Biosynthesis Halloween GeneInternational journal of molecular sciences · 2023Article
- Steroid receptor coactivator TAIMAN is a new modulator of insect circadian clock.PLoS genetics · 2023Article
- Developmental regulation of epithelial cell cuboidal-to-squamous transition in Drosophila follicle cells.Developmental biology · 2022Article
- Pruning deficits of the developingOpen biology · 2022Article
- Spatiotemporal gating of Stat nuclear influx byScience advances · 2022Article
- Border cell polarity and collective migration require the spliceosome component Cactin.The Journal of cell biology · 2022Article
- Drosophila USP22/nonstop polarizes the actin cytoskeleton during collective border cell migration.The Journal of cell biology · 2021Article
- Comparative transcriptome analyses of the Drosophila pupal eye.G3 (Bethesda, Md.) · 2021Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
During development, elaborate patterns of cell differentiation and movement must occur in the correct locations and at the proper times. Developmental timing has been studied less than spatial pattern formation, and the mechanisms integrating the two are poorly understood. Border-cell migration in the Drosophila ovary occurs specifically at stage 9. Timing of the migration is regulated by the steroid hormone ecdysone, whereas spatial patterning of the migratory population requires localized activity of the JAK-STAT pathway. Ecdysone signalling is patterned spatially as well as temporally, although the mechanisms are not well understood. In stage 9 egg chambers, ecdysone signalling is highest in anterior follicle cells including the border cells. We identify the gene abrupt as a repressor of ecdysone signalling and border-cell migration. Abrupt protein is normally lost from border-cell nuclei during stage 9, in response to JAK-STAT activity. This contributes to the spatial pattern of the ecdysone response. Abrupt attenuates ecdysone signalling by means of a direct interaction with the basic helix-loop-helix (bHLH) domain of the P160 ecdysone receptor coactivator Taiman (Tai). Taken together, these findings provide a molecular mechanism by which spatial and temporal cues are integrated.
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