Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

10 citing papers in PubMed.

1. Leptin as a modulator of neuroendocrine function in humans.Yonsei medical journal · 2012
   Review
2. Leptin in relation to the lipodystrophy-associated metabolic syndrome.Diabetes & metabolism journal · 2012
   Article
3. Leptin in human physiology and pathophysiology.American journal of physiology. Endocrinology and metabolism · 2011
   Review
4. Repositioning leptin as a therapy for Alzheimer's disease.Therapy (London, England : 2004) · 2011
   Article
5. Longitudinal assessment of metabolic abnormalities in adolescents and young adults with HIV-infection acquired perinatally or in early childhood.Metabolism: clinical and experimental · 2011
   Article
6. Body fat redistribution and metabolic abnormalities in HIV-infected patients on highly active antiretroviral therapy: novel insights into pathophysiology and emerging opportunities for treatment.Metabolism: clinical and experimental · 2011
   Article
7. Lipodystrophy: pathophysiology and advances in treatment.Nature reviews. Endocrinology · 2011
   Review
8. Leptin in human physiology and therapeutics.Frontiers in neuroendocrinology · 2010
   Review
9. Narrative review: the role of leptin in human physiology: emerging clinical applications.Annals of internal medicine · 2010
   Review
10. Leptin deficiency: clinical implications and opportunities for therapeutic interventions.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2009
    Review

Corrections and comments

• Comment on
  The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus-associated lipoatrophy and hypoleptinemia.2009

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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