ArticleThe Journal of experimental medicine2009
Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse.
Article in The Journal of experimental medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 2 citations in OpenAlex.
- Off-Label Uses of Abrocitinib: Review of Emerging Therapeutic Applications beyond Atopic Dermatitis.Life (Basel, Switzerland) · 2024Review
- Restriction of Viral Replication, Rather than T Cell Immunopathology, Drives Lethality in Murine Norovirus CR6-Infected STAT1-Deficient Mice.Journal of virology · 2022Article
- TREM-2 promotes Th1 responses by interacting with the CD3ζ-ZAP70 complex following Mycobacterium tuberculosis infection.The Journal of clinical investigation · 2021Article
- The Effects of Interferons on Allogeneic T Cell Response in GVHD: The Multifaced Biology and Epigenetic Regulations.Frontiers in immunology · 2021Review
- Targeting the Janus Kinase Family in Autoimmune Skin Diseases.Frontiers in immunology · 2019Review
- Inhibition of Cdk8/Cdk19 Activity Promotes Treg Cell Differentiation and Suppresses Autoimmune Diseases.Frontiers in immunology · 2019Article
- The Regulatory Role of IFN-γ on the Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.Stem cell reviews and reports · 2017Review
- IL-4-producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Interleukin-35 on B cell and T cell induction and regulation.Journal of inflammation (London, England) · 2017Review
- Ubiquitin Ligases and Deubiquitinating Enzymes in CD4+ T Cell Effector Fate Choice and Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Immune synapse: conductor of orchestrated organelle movement.Trends in cell biology · 2014Review
- The potential for genetically altered microglia to influence glioma treatment.CNS & neurological disorders drug targets · 2013Review
- Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells.Nature immunology · 2013Article
- Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation.Genome research · 2013Article
- The dynamic lives of T cells: new approaches and themes.Trends in immunology · 2013Review
- "Cell biology meets physiology: functional organization of vertebrate plasma membranes"--the immunological synapse.Current topics in membranes · 2013Article
- IL-12 family cytokines: immunological playmakers.Nature immunology · 2012Review
- Genes involved in systemic and arterial bed dependent atherosclerosis--Tampere Vascular study.PloS one · 2012Article
- Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.Nature immunology · 2011Article
- Bone resorption and remodeling in murine collagenase-induced osteoarthritis after administration of glucosamine.Arthritis research & therapy · 2011Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
The antigen recognition interface formed by T helper precursors (Thps) and antigen-presenting cells (APCs), called the immunological synapse (IS), includes receptors and signaling molecules necessary for Thp activation and differentiation. We have recently shown that recruitment of the interferon-gamma receptor (IFNGR) into the IS correlates with the capacity of Thps to differentiate into Th1 effector cells, an event regulated by signaling through the functionally opposing receptor to interleukin-4 (IL4R). Here, we show that, similar to IFN-gamma ligation, TCR stimuli induce the translocation of signal transducer and activator of transcription 1 (STAT1) to IFNGR1-rich regions of the membrane. Unexpectedly, STAT1 is preferentially expressed, is constitutively serine (727) phosphorylated in Thp, and is recruited to the IS and the nucleus upon TCR signaling. IL4R engagement controls this process by interfering with both STAT1 recruitment and nuclear translocation. We also show that in cells with deficient Th1 or constitutive Th2 differentiation, the IL4R is recruited to the IS. This observation suggest that the IL4R is retained outside the IS, similar to the exclusion of IFNGR from the IS during IL4R signaling. This study provides new mechanistic cues for the regulation of lineage commitment by mutual immobilization of functionally antagonistic membrane receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.