Stem cells are not proarrhythmic: letting the genie out of the bottle.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Periprocedural adverse events in cell therapy trials in myocardial infarction and cardiomyopathy: a systematic review.Clinical research in cardiology : official journal of the German Cardiac Society · 2013
   Pooled it
2. Direct intramyocardial transthoracic transplantation of bone marrow mononuclear cells for non-ischemic dilated cardiomyopathy: INTRACELL, a prospective randomized controlled trial.Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular
   Trial
3. Arrhythmogenic risks of stem cell replacement therapy for cardiovascular diseases.Journal of cellular physiology · 2020
   Review
4. What's in a cardiomyocyte - And how do we make one through reprogramming?Biochimica et biophysica acta. Molecular cell research · 2020
   Review
5. Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Ischaemic-Reperfused Hearts in Adult Rats with Established Chronic Kidney Disease.International journal of stem cells · 2019
   Article
6. Heart regeneration, stem cells, and cytokines.Regenerative medicine research · 2014
   Review
7. Bone marrow mesenchymal stem cells protected post-infarcted myocardium against arrhythmias via reversing potassium channels remodelling.Journal of cellular and molecular medicine · 2014
   Article
8. Induced pluripotent stem cells for post-myocardial infarction repair: remarkable opportunities and challenges.Circulation research · 2014
   Review
9. Comparison of cardiac stem cells and mesenchymal stem cells transplantation on the cardiac electrophysiology in rats with myocardial infarction.Stem cell reviews and reports · 2013
   Article
10. Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction.Circulation. Arrhythmia and electrophysiology · 2012
    Article
11. Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges.European heart journal · 2011
    Review
12. Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction.Journal of cellular and molecular medicine · 2011
    Review
13. Growth factor-induced mobilization of cardiac progenitor cells reduces the risk of arrhythmias, in a rat model of chronic myocardial infarction.PloS one · 2011
    Article
14. Cardiac cell repair therapy: a clinical perspective.Mayo Clinic proceedings · 2009
    Review

Corrections and comments

• Comment on
  Stem cell therapy is proarrhythmic.2009

Authors and funding

2 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as