Stem cell therapy is proarrhythmic.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Exploring mitochondrial health and transplantation strategies in DCD heart transplantation: a systematic review.Journal of translational medicine · 2025
   Pooled it
2. Periprocedural adverse events in cell therapy trials in myocardial infarction and cardiomyopathy: a systematic review.Clinical research in cardiology : official journal of the German Cardiac Society · 2013
   Pooled it
3. Direct intramyocardial transthoracic transplantation of bone marrow mononuclear cells for non-ischemic dilated cardiomyopathy: INTRACELL, a prospective randomized controlled trial.Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular
   Trial
4. Administration of Single or Repeated Doses of CDCs in a Swine Model of Reperfused Myocardial Infarction: Magnetic Resonance and Proteomics Evaluation.International journal of molecular sciences · 2025
   Article
5. Atrial fibrillation or flutter in patients undergoing stem cell transplantation, in-hospital and post-discharge outcomes in a large nationwide sample across the United States.Cardio-oncology (London, England) · 2025
   Article
6. Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases.Journal of nanobiotechnology · 2025
   Review
7. Effects of Mesenchymal Stem Cell Injection into Healed Myocardial Infarction Scar Border Zone on the Risk of Ventricular Tachycardia.Biomedicines · 2023
   Article
8. Intrapericardial Delivery of APA-Microcapsules as Promising Stem Cell Therapy Carriers in an Experimental Acute Myocardial Infarction Model.Pharmaceutics · 2021
   Article
9. Enhancing cardiac reprogramming via synthetic RNA oligonucleotides.Molecular therapy. Nucleic acids · 2021
   Article
10. Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications.Frontiers in cardiovascular medicine · 2021
    Review
11. What's in a cardiomyocyte - And how do we make one through reprogramming?Biochimica et biophysica acta. Molecular cell research · 2020
    Review
12. Stem Cell Extracellular Vesicles in Skin Repair.Bioengineering (Basel, Switzerland) · 2018
    Review
13. Prediction of therapeutic effects of human cardiomyocytes in myocardial infarction using non-human primates model.Annals of translational medicine · 2018
    Article
14. Controlled Release of Collagen-Binding SDF-1α Improves Cardiac Function after Myocardial Infarction by Recruiting Endogenous Stem Cells.Scientific reports · 2016
    Article
15. Spontaneous inward currents reflecting oscillatory activation of Na⁺/Ca²⁺ exchangers in human embryonic stem cell-derived cardiomyocytes.Pflugers Archiv : European journal of physiology · 2016
    Article
16. Direct reprogramming and biomaterials for controlling cell fate.Biomaterials research · 2016
    Review
17. A novel high throughput approach to screen for cardiac arrhythmic events following stem cell treatment.Medical hypotheses · 2015
    Article
18. Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury.American journal of physiology. Heart and circulatory physiology · 2013
    Article
19. Genetic engineering of somatic cells to study and improve cardiac function.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2012
    Article
20. Effect of skeletal muscle Na(+) channel delivered via a cell platform on cardiac conduction and arrhythmia induction.Circulation. Arrhythmia and electrophysiology · 2012
    Article

Corrections and comments

• Commented on by
  Stem cells are not proarrhythmic: letting the genie out of the bottle.2009

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as