Trial reportCirculation2009
Lifestyle interventions reduce coronary heart disease risk: results from the PREMIER Trial.
Trial report in Circulation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03720327 (Fitness Intensive Therapy), which is not on this map. Cited by 106 papers, 13 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fitness Intensive Therapy (Get FIT) to Promote Healthy Living in Older Adults
Who cites it
106 citing papers in PubMed, 13 syntheses or guidelines pooled it.
- Dietary Approaches to Stop Hypertension (DASH) for the primary and secondary prevention of cardiovascular diseases.The Cochrane database of systematic reviews · 2025Pooled it
- Effective Behavior Change Techniques in Digital Health Interventions for the Prevention or Management of Noncommunicable Diseases: An Umbrella Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023Pooled it
- Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of total fat intake on body fatness in adults.The Cochrane database of systematic reviews · 2020Pooled it
- Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2017Pooled it
- Effects of total fat intake on body weight.The Cochrane database of systematic reviews · 2015Pooled it
- Hypertension and overweight/obesity in Ghanaians and Nigerians living in West Africa and industrialized countries: a systematic review.Journal of hypertension · 2014Pooled it
- Avoiding weight gain in cardiometabolic disease: a systematic review.Journal of obesity · 2014Pooled it
- Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2012Pooled it
- Weight loss and African-American women: a systematic review of the behavioural weight loss intervention literature.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2012Pooled it
- Reduced or modified dietary fat for preventing cardiovascular disease.The Cochrane database of systematic reviews · 2011Pooled it
- The association between neighborhood conditions and weight loss among older adults living in a large urban city.Journal of behavioral medicine · 2023Trial
- Fit-cardiopulmonary resuscitation approach in public mass cardiopulmonary resuscitation teaching: A randomized control trial.Saudi medical journal · 2023Trial
- Efficacy of supermarket and web-based interventions for improving dietary quality: a randomized, controlled trial.Nature medicine · 2022Trial
- Trial
- Effect of a Comprehensive Cardiovascular Risk Reduction Intervention in Persons With Serious Mental Illness: A Randomized Clinical Trial.JAMA network open · 2020Trial
- Dose-dependent effects of lifestyle interventions on blood lipid levels: Results from the PREMIER trial.Patient education and counseling · 2019Trial
- Efficacy of a church-based lifestyle intervention programme to control high normal blood pressure and/or high normal blood glucose in church members: a randomized controlled trial in Pretoria, South Africa.BMC public health · 2014Trial
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundAlthough trials of lifestyle interventions generally focus on cardiovascular disease risk factors rather than hard clinical outcomes, 10-year coronary heart disease (CHD) risk can be estimated from the Framingham risk equations. Our objectives were to study the effect of 2 multicomponent lifestyle interventions on estimated CHD risk relative to advice alone and to evaluate whether differences can be observed in the effects of the lifestyle interventions among subgroups defined by baseline variables. METHODS AND
resultsA total of 810 healthy adults with untreated prehypertension or stage I hypertension were randomized to 1 of 3 intervention groups: An "advice-only" group, an "established" group that used established lifestyle recommendations for blood pressure control (sodium reduction, weight loss, and increased physical activity), or an "established-plus-DASH" group that combined established lifestyle recommendations with the DASH (Dietary Approaches to Stop Hypertension) diet. The primary outcome was 10-year CHD risk, estimated from follow-up data collected at 6 months. A secondary outcome was 10-year CHD risk at 18 months. Of the 810 participants, 62% were women and 34% were black. Mean age was 50 years, mean systolic/diastolic blood pressure was 135/85 mm Hg, and median baseline Framingham risk was 1.9%. The relative risk ratio comparing 6-month to baseline Framingham risk was 0.86 (95% confidence interval 0.81 to 0.91, P<0.001) in the established group and 0.88 (95% confidence interval 0.83 to 0.94, P<0.001) in the established-plus-DASH group relative to advice alone. Results were virtually identical in sensitivity analyses, in each major subgroup, and at 18 months.
conclusionsThe observed reductions of 12% to 14% in estimated CHD risk are substantial and, if achieved, should have important public health benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.