Evidence map›Paper›PMID 19349248›Full record

ReviewIEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society

Multiscale models of angiogenesis.

Amina A Qutub, Feilim Mac Gabhann, Emmanouil D Karagiannis, Prakash Vempati, Aleksander S Popel

Erratum issuedAbstract readReview
In one paragraph

Review in IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 154 citations in OpenAlex.

  1. Review
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  14. Sex differences in cancer mechanisms.Biology of sex differences · 2020
    Review
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Amina A QutubDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA. aqutub@jhu.edu
Feilim Mac Gabhann
Emmanouil D Karagiannis
Prakash Vempati
Aleksander S Popel
Johns Hopkins Medicine · USJohns Hopkins University · USMassachusetts Institute of Technology · USUniversity of Virginia · US

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Systems Biology of Angiogenesis in Peripheral Arterial DiseaseR01HL101200 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2010 to 2022
$10.7M
Predictive experiment-based multiscale models of the tumor immune microenvironment and immunotherapy in breast cancerR01CA138264 · NCI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2009 to 2023
$8.1M
Quantitative Analysis of Angiogenesis in Skeletal MuscleR01HL079653 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2005 to 2009
$1.5M
Systems Biology of Angiogenesis: Molecules to therapyR33HL087351 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2006 to 2008
$1.3M
Endothelial cell decisions integrate soluble and matrix-bound VEGF gradientsR00HL093219 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MAC GABHANN, FEILIM C · 2009 to 2011
$746k
Modeling Intracellular Mechanisms of Hypoxic ResponseF32HL085016 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI QUTUB, AMINA ANN · 2006 to 2008
$145k
NCI NIH HHS R01 CA138264NHLBI NIH HHS 1F32HL085016-01NHLBI NIH HHS F32 HL085016NHLBI NIH HHS R00 HL093219NHLBI NIH HHS R01 HL079653NHLBI NIH HHS R01 HL101200NHLBI NIH HHS R01 HL79653NHLBI NIH HHS R33 HL087351NHLBI NIH HHS T32 HL007284NHLBI NIH HHS T32 HL7284
6 · The paper itself

Abstract

Vascular disease, cancer, stroke, neurodegeneration, diabetes, inflammation, asthma, obesity, arthritis--the list of conditions that involve angiogenesis reads like main chapters in a book on pathology. Angiogenesis, the growth of capillaries from preexisting vessels, also occurs in normal physiology, in response to exercise or in the process of wound healing.Why and when is angiogenesis prevalent? What controls the process? How can we intelligently control it? These are the key questions driving researchers in fields as diverse as cell biology, oncology, cardiology, neurology, biomathematics, systems biology, and biomedical engineering. As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia.

Indexed as

Models, CardiovascularNeovascularization, PhysiologicComputational BiologyComputer SimulationHumansHypoxia-Inducible Factor 1Matrix MetalloproteinasesVascular Endothelial Growth Factor AHypoxia-Inducible Factor 1Matrix MetalloproteinasesVascular Endothelial Growth Factor A

Identifiers

PMID19349248
PMCPMC3077679
OpenAlexW2038408091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.