ArticleNeuroImage2009
Hyperstimulation of striatal D2 receptors with sleep deprivation: Implications for cognitive impairment.
Article in NeuroImage, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Delayed match-to-sample in working memory: A BrainMap meta-analysis.Biological psychology · 2016Pooled it
- Trial
- Targeting Sleep to Improve Outcomes in Psychosis: Digital and Non-Pharmacological Interventions.Medicina (Kaunas, Lithuania) · 2026Review
- Reduced but Reversible Brain Entropy After Occupational Partial Sleep Deprivation in Night-Shift Medical Staff.Brain and behavior · 2026Article
- Poor Sleep Quality and Mood Disorders: Risk Factors of Increasing Chronic Pain in Patients with Insomnia.Nature and science of sleep · 2025Article
- Linking Sleep and Aggression: Examining the Role of Response Inhibition and Emotional Processing.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Enhancement of cue-induced reinstatement of alcohol seeking by acute total sleep restriction in male Wistar rats.Pharmacology, biochemistry, and behavior · 2021Article
- Novel PET Biomarkers to Disentangle Molecular Pathways across Age-Related Neurodegenerative Diseases.Cells · 2020Review
- Mapping the landscape of human dopamine D2/3 receptors with [Brain structure & function · 2019Article
- Sleep disturbances and depression severity in patients with Parkinson's disease.Brain and behavior · 2018Article
- Circadian and Homeostatic Modulation of Multi-Unit Activity in Midbrain Dopaminergic Structures.Scientific reports · 2018Article
- The effects of sleep deprivation on item and associative recognition memory.Journal of experimental psychology. Learning, memory, and cognition · 2018Article
- Functional Polymorphisms in Dopaminergic Genes Modulate Neurobehavioral and Neurophysiological Consequences of Sleep Deprivation.Scientific reports · 2017Article
- Association between striatal dopamine D2/D3 receptors and brain activation during visual attention: effects of sleep deprivation.Translational psychiatry · 2016Article
- Reduced sleep duration mediates decreases in striatal D2/D3 receptor availability in cocaine abusers.Translational psychiatry · 2016Article
- Balanced modulation of striatal activation from D2 /D3 receptors in caudate and ventral striatum: Disruption in cannabis abusers.Human brain mapping · 2015Article
- Retinal dysfunction of contrast processing in major depression also apparent in cortical activity.European archives of psychiatry and clinical neuroscience · 2015Article
- The role of sleep in emotional brain function.Annual review of clinical psychology · 2014Review
- The association of sleep and pain: an update and a path forward.The journal of pain · 2013Review
- Sleep deprivation amplifies striatal activation to monetary reward.Psychological medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Sleep deprivation interferes with cognitive performance but the mechanisms are poorly understood. We recently reported that one night of sleep deprivation increased dopamine in striatum (measured with [(11)C]raclopride, a PET radiotracer that competes with endogenous dopamine for binding to D2 receptors) and that these increases were associated with impaired performance in a visual attention task. To better understand this association here we evaluate the relationship between changes in striatal dopamine (measured as changes in D2 receptor availability using PET and [(11)C]raclopride) and changes in brain activation to a visual attention task (measured with BOLD and fMRI) when performed during sleep deprivation versus during rested wakefulness. We find that sleep induced changes in striatal dopamine were associated with changes in cortical brain regions modulated by dopamine (attenuated deactivation of anterior cingulate gyrus and insula) but also in regions that are not recognized targets of dopaminergic modulation (attenuated activation of inferior occipital cortex and cerebellum). Moreover, the increases in striatal dopamine as well as its associated regional activation and deactivation patterns correlated negatively with performance accuracy. These findings therefore suggest that hyperstimulation of D2 receptors in striatum may contribute to the impairment in visual attention during sleep deprivation. Thus, while dopamine increases in prefrontal regions (including stimulation of D1 receptors) may facilitate attention our findings suggest that hyperstimulation of D2 receptors in striatum may impair it. Alternatively, these associations may reflect a compensatory striatal dopamine response (to maintain arousal) that is superimposed on a larger response to sleep deprivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.