ArticleNeuroImage2009
Genetic dissection of the mouse brain using high-field magnetic resonance microscopy.
Article in NeuroImage, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Investigating Motor Coordination Using BXD Recombinant Inbred Mice to Model the Genetic Underpinnings of Developmental Coordination Disorder.Genes, brain, and behavior · 2025Article
- The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI.Frontiers in cellular neuroscience · 2024Article
- Developmental coordination disorder: What can we learn from RI mice using motor learning tasks and QTL analysis.Genes, brain, and behavior · 2023Article
- Merged magnetic resonance and light sheet microscopy of the whole mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Variability and heritability of mouse brain structure: Microscopic MRI atlases and connectomes for diverse strains.NeuroImage · 2020Article
- Small Animal Multivariate Brain Analysis (SAMBA) - a High Throughput Pipeline with a Validation Framework.Neuroinformatics · 2019Article
- Volumes of brain structures in captive wild-type and laboratory rats: 7T magnetic resonance in vivo automatic atlas-based study.PloS one · 2019Article
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- The organization of frequency and binaural cues in the gerbil inferior colliculus.The Journal of comparative neurology · 2017Article
- Quantitative mapping of trimethyltin injury in the rat brain using magnetic resonance histology.Neurotoxicology · 2014Article
- Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.PloS one · 2014Article
- Adolescent binge ethanol treatment alters adult brain regional volumes, cortical extracellular matrix protein and behavioral flexibility.Pharmacology, biochemistry, and behavior · 2014Article
- Quantitative mouse brain phenotyping based on single and multispectral MR protocols.NeuroImage · 2012Article
- 3D magnetic resonance microscopy of the ex vivo retina.Magnetic resonance in medicine · 2012Article
- Genetic, morphometric, and behavioral factors linked to the midsagittal area of the corpus callosum.Frontiers in genetics · 2012Article
- Sex-specific modulation of gene expression networks in murine hypothalamus.Frontiers in neuroscience · 2012Article
- Mapping behavioural evolution onto brain evolution: the strategic roles of conserved organization in individuals and species.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Review
- Microscopic diffusion tensor atlas of the mouse brain.NeuroImage · 2011Article
- Identifying human disease genes through cross-species gene mapping of evolutionary conserved processes.PloS one · 2011Article
- CNS animal fMRI in pain and analgesia.Neuroscience and biobehavioral reviews · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Magnetic resonance (MR) imaging has demonstrated that variation in brain structure is associated with differences in behavior and disease state. However, it has rarely been practical to prospectively test causal models that link anatomical and functional differences in humans. In the present study we have combined classical mouse genetics with high-field MR to systematically explore and test such structure-functional relations across multiple brain regions. We segmented 33 regions in two parental strains-C57BL/6J (B) and DBA/2J (D)-and in nine BXD recombinant inbred strains. All strains have been studied extensively for more than 20 years using a battery of genetic, functional, anatomical, and behavioral assays. We compared levels of variation within and between strains and sexes, by region, and by system. Average within-strain variation had a coefficient of variation (CV) of 1.6% for the whole brain; while the CV ranged from 2.3 to 3.6% for olfactory bulbs, cortex and cerebellum, and up to approximately 18% for septum and laterodorsal thalamic nucleus. Variation among strain averages ranged from 6.7% for cerebellum, 7.6% for whole brain, 9.0% for cortex, up to approximately 26% for the ventricles, laterodorsal thalamic nucleus, and the interpeduncular nucleus. Heritabilities averaged 0.60+/-0.18. Sex differences were not significant with the possible (and unexpected) exception of the pons ( approximately 20% larger in males). A correlation matrix of regional volumes revealed high correlations among functionally related parts of the CNS (e.g., components of the limbic system), and several high correlations between regions that are not anatomically connected, but that may nonetheless be functionally or genetically coupled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.