ArticleThe Journal of allergy and clinical immunology2009
Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization.
Article in The Journal of allergy and clinical immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Subcutaneous Injection and Brush Application of Ovalbumin-Aluminum Salt Solution Induces Dermatitis-like Changes in Mice.Journal of clinical medicine · 2025Article
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- Analysis of gene expression difference and biological process in chorionic villi of unexplained recurrent spontaneous abortion.BMC pregnancy and childbirth · 2024Article
- Phytochemical Investigation ofPharmaceuticals (Basel, Switzerland) · 2023Article
- The PLAUR signaling promotes chronic pruritus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- The Role of Decorin in Autoimmune and Inflammatory Diseases.Journal of immunology research · 2022Review
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- Article
- The Role of Toll-Like Receptors in Skin Host Defense, Psoriasis, and Atopic Dermatitis.Journal of immunology research · 2019Review
- Regulation of contact sensitivity in non-obese diabetic (NOD) mice by innate immunity.Contact dermatitis · 2018Article
- Impaired Toll-like receptor 2-mediated Th1 and Th17/22 cytokines secretion in human peripheral blood mononuclear cells from patients with atopic dermatitis.Journal of translational medicine · 2015Article
- Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus.The Journal of allergy and clinical immunology · 2015Article
- Toll-like receptor 3 increases allergic and irritant contact dermatitis.The Journal of investigative dermatology · 2015Article
- Exacerbation of allergen-induced eczema in TLR4- and TRIF-deficient mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Decorin potentiates interferon-γ activity in a model of allergic inflammation.The Journal of biological chemistry · 2013Article
- Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair.The Journal of investigative dermatology · 2013Article
- Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis.The Journal of allergy and clinical immunology · 2013Article
- Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis.Autoimmunity · 2012Review
- Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Characterization of NLRP12 during the development of allergic airway disease in mice.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAtopic dermatitis and allergic contact dermatitis are skin disorders triggered by epicutaneous sensitization with protein antigens and contact sensitization with haptens, respectively. Skin is colonized with bacteria, which are a source of Toll-like receptor (TLR) 2 ligands.
objectiveWe sought to examine the role of TLR2 in murine models of atopic dermatitis and allergic contact dermatitis.
methodsTLR2(-/-) mice and wild-type littermates were epicutaneously sensitized with ovalbumin (OVA) or contact sensitized with oxazolone (OX). Skin histology was assessed by means of hematoxylin and eosin staining and immunohistochemistry. Ear swelling was measured with a micrometer. Cytokine mRNA expression was examined by means of quantitative RT-PCR. Antibody levels and splenocyte secretion of cytokines in response to OVA stimulation were measured by means of ELISA. Dendritic cells were examined for their ability to polarize T-cell receptor/OVA transgenic naive T cells to T(H)1 and T(H)2.
resultsIn response to OVA sensitization, TLR2(-/-) mice experienced skin infiltration with eosinophils and CD4(+) cells, as well as upregulation of T(H)2 cytokine mRNAs that was comparable with that seen in wild-type littermates. In contrast, epidermal thickening, IFN-gamma expression in the skin, IFN-gamma production by splenocytes, and IgG2a anti-OVA antibody levels were impaired in TLR2(-/-) mice. After OX ear challenge, contact sensitized TLR2(-/-) mice exhibited defective ear swelling with impaired cellular infiltration, decreased epidermal thickening and local IFN-gamma expression, and impaired OX-specific IgG2a responses. Dendritic cells from TLR2(-/-) mice induced significantly lower production of IFN-gamma but normal IL-4 and IL-13 production in naive T cells.
conclusionsThese results indicate that TLR2 promotes the IFN-gamma response to cutaneously introduced antigens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.