ArticleBrain, behavior, and immunity2009
Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection.
Article in Brain, behavior, and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Double-edged effects of tamoxifen-in-oil-gavage on an infectious murine model for multiple sclerosis.Brain pathology (Zurich, Switzerland) · 2021Article
- Immune response of frontline medical workers providing medical support for Wuhan COVID-19 patients, China.International immunopharmacology · 2021Article
- Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and Stress.Frontiers in immunology · 2021Review
- Control of immunity by glucocorticoids in health and disease.Seminars in immunopathology · 2020Review
- Indoleamine 2,3-dioxygenase 1 deletion promotes Theiler's virus-induced seizures in C57BL/6J mice.Epilepsia · 2019Article
- Spleen contributes to restraint stress induced changes in blood leukocytes distribution.Scientific reports · 2017Article
- Influenza infection triggers disease in a genetic model of experimental autoimmune encephalomyelitis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The association between maternal psychological stress and inflammatory cytokines in allergic young children.PeerJ · 2016Article
- Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.The Journal of biological chemistry · 2013Article
- Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection.Journal of neuroimmunology · 2013Article
- Chronic psychological stress induces the accumulation of myeloid-derived suppressor cells in mice.PloS one · 2013Article
- Social disruption induced priming of CNS inflammatory response to Theiler's virus is dependent upon stress induced IL-6 release.Journal of neuroimmunology · 2011Article
- Poly(I:C) promotes TNFα/TNFR1-dependent oligodendrocyte death in mixed glial cultures.Journal of neuroinflammation · 2011Article
- A marked reduction in priming of cytotoxic CD8+ T cells mediated by stress-induced glucocorticoids involves multiple deficiencies in cross-presentation by dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated.Journal of neuroinflammation · 2010Article
- Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity.Journal of neuroimmunology · 2010Article
- Neonatal maternal separation alters immune, endocrine, and behavioral responses to acute Theiler's virus infection in adult mice.Behavior genetics · 2010Article
- Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Restraint stress fails to render C57BL/6 mice susceptible to Theiler's virus-induced demyelination.Neuroimmunomodulation · 2010Article
- Effects of stress on the immune response to Theiler's virus--implications for virus-induced autoimmunity.Neuroimmunomodulation · 2010Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Multiple sclerosis (MS) is a devastating CNS disease of unknown origin. Multiple factors including genetic background, infection, and psychological stress affect the onset or progression of MS. Theiler's murine encephalomyelitis virus (TMEV) infection is an animal model of MS in which aberrant immunity leads to viral persistence and subsequently results in demyelination that resembles MS. Here, we examined how stress during acute TMEV infection altered virus-specific cell mediated responses. Using immunodominant viral peptides specific for either CD4(+) or CD8(+) T cells, we found that stress reduced IFN-gamma producing virus-specific CD4(+) and CD8(+) T cells in the spleen and CD8(+) T cells CNS. Cytokine production by cells isolated from the CNS or spleens following stimulation with virus or viral peptides, indicated that stress decreased both type 1 and type 2 responses. Glucocorticoids were implicated in the decreased T cell function as the effects of stress were partially reversed by concurrent RU486 administration but mimicked by dexamethasone. As T cells mediate viral clearance in this model, our data support the hypothesis that stress-induced immunosuppression may provide a mechanism for enhanced viral persistence within the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.