ArticleBiophysical journal2009
Dynamics of tRNA at different levels of hydration.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 98 citations in OpenAlex.
- Decoupling of the onset of anharmonicity between a protein and its surface water around 200 K.eLife · 2024Article
- Probing the structure of human tRNARSC advances · 2023Article
- Coherent X-ray Scattering Reveals Nanoscale Fluctuations in Hydrated Proteins.The journal of physical chemistry. B · 2023Article
- Universal dynamical onset in water at distinct material interfaces.Chemical science · 2022Article
- Structural alphabets for conformational analysis of nucleic acids available at dnatco.datmos.org.Acta crystallographica. Section D, Structural biology · 2020Article
- Determination of Dynamical Heterogeneity from Dynamic Neutron Scattering of Proteins.Biophysical journal · 2018Article
- MD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and Allostery.International journal of molecular sciences · 2015Review
- Slowdown of Interhelical Motions Induces a Glass Transition in RNA.Biophysical journal · 2015Article
- NMR Water Self-Diffusion and Relaxation Studies on Sodium Polyacrylate Solutions and Gels in Physiologic Ionic Solutions.Journal of applied polymer science · 2014Article
- Dynamics of protein and its hydration water: neutron scattering studies on fully deuterated GFP.Biophysical journal · 2012Article
- Role of methyl groups in dynamics and evolution of biomolecules.Journal of biological physics · 2012Article
- Hydrostatic and osmotic pressure study of the RNA hydration.Molecular biology reports · 2012Article
- Solvent effect on librational dynamics of spin-labelled haemoglobin by ED- and CW-EPR.European biophysics journal : EBJ · 2011Article
- Molecular crowding stabilizes folded RNA structure by the excluded volume effect.Journal of the American Chemical Society · 2010Article
- Mean-squared atomic displacements in hydrated lysozyme, native and denatured.Journal of biological physics · 2010Article
- Dynamics of biological macromolecules: not a simple slaving by hydration water.Biophysical journal · 2010Article
- Single molecule detection of direct, homologous, DNA/DNA pairing.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of hydration on the nanosecond timescale dynamics of tRNA is investigated using neutron scattering spectroscopy. Unlike protein dynamics, the dynamics of tRNA is not affected by methyl group rotation. This allows for a simpler analysis of the influence of hydration on the conformational motions in RNA. We find that hydration affects the dynamics of tRNA significantly more than that of lysozyme. Both the characteristic length scale and the timescale of the conformational motions in tRNA depend strongly on hydration. Even the characteristic temperature of the so-called "dynamical transition" appears to be hydration-dependent in tRNA. The amplitude of the conformational motions in fully hydrated tRNA is almost twice as large as in hydrated lysozyme. We ascribe these differences to a more open and flexible structure of hydrated RNA, and to a larger fraction and different nature of hydrophilic sites. The latter leads to a higher density of water that makes the biomolecule more flexible. All-atom molecular-dynamics simulations are used to show that the extent of hydration is greater in tRNA than in lysozyme. We propose that water acts as a "lubricant" in facilitating enhanced motion in solvated RNA molecules.
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