ArticleNature2009
Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.
Article in Nature, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
83 citing papers in PubMed, 169 citations in OpenAlex.
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- Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells.PLoS computational biology · 2025Article
- Modeling traveling calcium waves in cellular structures.Journal of computational neuroscience · 2025Article
- α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity.Cell reports · 2023Article
- Structural titration reveals CaNature communications · 2023Article
- Synergistic Interaction of 5-HTInternational journal of molecular sciences · 2023Article
- Understanding IPCell calcium · 2023Review
- Modeling IPBiophysical journal · 2023Article
- Ratiometric measurement of MAM CaNature communications · 2023Article
- Characterizing spontaneous CaBiophysical journal · 2022Article
- Mechanisms and physiological implications of cooperative gating of clustered ion channels.Physiological reviews · 2022Review
- Quantal CaCell reports · 2021Article
- IPProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Collective Dynamics of Ion Channels on Bilayer Lipid Membranes.ACS omega · 2021Article
- Modeling of Astrocyte Networks: Toward Realistic Topology and Dynamics.Frontiers in cellular neuroscience · 2021Article
- Spatial-temporal patterning of CaSeminars in cell & developmental biology · 2019Review
- The acidocalcisome inositol-1,4,5-trisphosphate receptor ofThe Journal of biological chemistry · 2019Article
- Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers.Biochimica et biophysica acta. Molecular cell research · 2019Article
- Role of Type 1 Inositol 1,4,5-triphosphate Receptors in Mammalian Oocytes.Development & reproduction · 2019Review
23 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The versatility of Ca2+ signals derives from their spatio-temporal organization. For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires local interactions between InsP3 receptors (InsP3Rs) mediated by their rapid stimulation and slower inhibition\ by cytosolic Ca2+. This allows hierarchical recruitment of Ca2+ release events as the InsP3 concentration increases. Single InsP3Rs respond first, then clustered InsP3Rs open together giving a local 'Ca2+ puff', and as puffs become more frequent they ignite regenerative Ca2+ waves. Using nuclear patch-clamp recording, here we demonstrate that InsP3Rs are initially randomly distributed with an estimated separation of 1 m. Low concentrations of InsP3 cause InsP3Rs to aggregate rapidly and reversibly into small clusters of about four closely associated InsP3Rs. At resting cytosolic [Ca2+], clustered InsP3Rs open independently, but with lower open probability, shorter open time, and less InsP3 sensitivity than lone InsP3Rs. Increasing cytosolic [Ca2+] reverses the inhibition caused by clustering, InsP3R gating becomes coupled, and the duration of multiple openings is prolonged. Clustering both exposes InsP3Rs to local Ca2+ rises and increases the effects of Ca2+. Dynamic regulation of clustering by InsP3 retunes InsP3R sensitivity to InsP3 and Ca2+, facilitating hierarchical recruitment of the elementary events that underlie all InsP3-evoked Ca2+ signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.