ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Restriction of ectopic eye formation by Drosophila teashirt and tiptop to the developing antenna.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
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- The timing of cell fate decisions is crucial for initiating pattern formation in the Drosophila eye.Development (Cambridge, England) · 2022Article
- Multiple loci linked to inversions are associated with eye size variation in species of the Drosophila virilis phylad.Scientific reports · 2020Article
- Human eye conditions: insights from the fly eye.Human genetics · 2019Review
- The fly eye: Through the looking glass.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Allocation of distinct organ fates from a precursor field requires a shift in expression and function of gene regulatory networks.PLoS genetics · 2018Article
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- Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.Developmental biology · 2017Review
- optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila.Developmental biology · 2013Article
- The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila.Development (Cambridge, England) · 2013Article
- Homeotic functions of the Teashirt transcription factor during adult Drosophila development.Biology open · 2013Article
- Homeotic Gene teashirt (tsh) has a neuroprotective function in amyloid-beta 42 mediated neurodegeneration.PloS one · 2013Article
- A glimpse into dorso-ventral patterning of the Drosophila eye.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Review
- A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity.Developmental biology · 2011Article
- My what big eyes you have: how the Drosophila retina grows.Developmental neurobiology · 2011Review
- Genetic feminization of the thoracic nervous system disrupts courtship song in male Drosophila melanogaster.Journal of neurogenetics · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In Drosophila, the retinal determination network comprises a set of nuclear factors whose loss-of-function phenotypes often include the complete or near total elimination of the developing eye. These genes also share the ability of being able to induce ectopic eye formation when forcibly expressed in nonretinal tissues such as the antennae, legs, halteres, wings, and genitals. However, it appears that the ability to redirect and transform tissue fates is limited; not all tissues and cell populations can be forced into adopting an eye fate. In this report, we demonstrate that ectopic eye formation by teashirt and its paralog tiptop, a potential new eye specification gene, is restricted to the developing antennae. Of interest, tiptop appears to be a more effective inducer of retinal formation than teashirt. A genetic screen for interacting proteins failed to identify paralog-specific relationships suggesting that the differences between these two genes may be attributed instead to structural differences between the duplicates. We also demonstrate that in addition to being expressed in coincident patterns within the developing eye, both paralogs are transcribed at very similar levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.