ArticleMuscle & nerve2009
Age-related fatigue resistance in the knee extensor muscles is specific to contraction mode.
Article in Muscle & nerve, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Pooled it
- Age-related Deficits in Voluntary Activation: A Systematic Review and Meta-analysis.Medicine and science in sports and exercise · 2020Pooled it
- Age-related differences in muscle fatigue vary by contraction type: a meta-analysis.Physical therapy · 2011Pooled it
- Systematic review and meta-analysis of skeletal muscle fatigue in old age.Medicine and science in sports and exercise · 2011Pooled it
- Neuromuscular fatigue in young and older men using constant or variable resistance.European journal of applied physiology · 2013Trial
- Age, muscle fatigue, and walking endurance in pre-menopausal women.European journal of applied physiology · 2011Trial
- Effects of acidosis and inorganic phosphate on CaAmerican journal of physiology. Cell physiology · 2026Article
- Are females getting more fatigable as they age?European journal of applied physiology · 2025Article
- Effects of Experimentally Induced Lower Limb Muscle Fatigue on Healthy Adults' Gait: A Systematic Review.Bioengineering (Basel, Switzerland) · 2025Review
- A knowledge-based equation of daily work exposure.PloS one · 2025Article
- A four-compartment controller model of muscle fatigue for static and dynamic tasks.Frontiers in physiology · 2025Article
- Age-related effects of neuromuscular fatigue and acute recovery responses on maximal and rapid torque measures of the leg extensors and flexors.European journal of applied physiology · 2024Article
- Modified Squat Test for Predicting Knee Muscle Strength in Older Adults.Annals of geriatric medicine and research · 2024Article
- Fetal muscle extract improves muscle function and performance in aged mice.Frontiers in physiology · 2022Article
- Fatigability of the knee extensor muscles during high-load fast and low-load slow resistance exercise in young and older adults.Experimental gerontology · 2021Article
- High-Intensity Interval Training for Knee Osteoarthritis: A Pilot Study.ACR open rheumatology · 2021Article
- Influence of the medial longitudinal arch of the foot in adult women in ankle isokinetic performance: a cross-sectional study.Journal of foot and ankle research · 2021Article
- Heart failure with preserved ejection fraction diminishes peripheral hemodynamics and accelerates exercise-induced neuromuscular fatigue.American journal of physiology. Heart and circulatory physiology · 2021Article
- Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson's disease and older adults: A pilot study.Clinical parkinsonism & related disorders · 2021Article
- Greater fatigability and motor unit discharge variability in human type 2 diabetes.Physiological reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The question of whether skeletal muscle fatigue is preserved or enhanced in older adults is a point of controversy. Disparate findings may be attributed to differences in subject population and study protocols, including contraction mode. The purpose of this study was to test the hypotheses that healthy older (65-80 years of age, 8 males and 8 females) adults who were matched to young adults (21-35 years of age; 8 males and 8 females) with similar physical activity levels would: (1) fatigue less during isometric knee extensor (KE) contractions, but (2) would show similar fatigue during dynamic KE contractions performed at 120 degrees s(-1). Fatigue was induced with 4 minutes of intermittent, isometric, or dynamic maximal voluntary contractions, performed on separate days. Electrically stimulated contractions were used to evaluate central activation during both fatigue protocols. Older subjects maintained a higher percentage of baseline maximum voluntary contraction (MVC) torque than young subjects during isometric contractions (mean +/- SE: 71 +/- 3% and 57 +/- 3%, respectively, P < 0.01). In contrast, there was no difference between age groups in torque maintenance during dynamic contractions (43 +/- 3% and 44 +/- 3%, respectively, P = 0.86). For both groups, changes in electrically stimulated and voluntary contractions followed similar trends, suggesting that central activation did not play a role in the age-related differences in fatigue. Fatigue during the isometric protocol was associated with fatigue during the dynamic protocol in the young group only (r = 0.62, P = 0.01), suggesting that distinct mechanisms influence fatigue during isometric and dynamic contractions in older adults. Muscle Nerve 39: 692-702, 2009.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.